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. 2016 Sep 21;13:156. doi: 10.1186/s12985-016-0616-1

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Breakpoint frequency in near full-length URF and CRF groups. a The breakpoint distribution of URFs from Asia. b The breakpoint distribution of URFs from Africa. c The breakpoint distribution of URFs from Europe. d The breakpoint distribution of global CRFs. e The integrated distribution of the 4 groups. f The hot regions and cold regions and corresponding gene locations. The breakpoint positions are based on the HXB2 numbering (from HXB2 790 nt to 9417 nt). Horizontal blue lines: average frequency value per window; horizontal red lines: hot spot boundary line; horizontal black lines: cold spot boundary line. Frequency scales are some different in each panel for better resolution