Table 2.
The Gene Ontology (GO) biological process and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of differentially expressed genes
| Type | Category | Term | Count | P-value |
|---|---|---|---|---|
| GO | ||||
| Down-regulated genes | ||||
| GO:0045667 | regulation of osteoblast differentiation | 3 | 0.00816 | |
| GO:0051345 | positive regulation of hydrolase activity | 4 | 0.018904 | |
| GO:0030278 | regulation of ossification | 3 | 0.025314 | |
| GO:0010638 | positive regulation of organelle organization | 3 | 0.028404 | |
| GO:0045596 | negative regulation of cell differentiation | 4 | 0.030755 | |
| GO:0002076 | osteoblast development | 2 | 0.03129 | |
| GO:0045736 | regulation of cyclin-dependent protein kinase activity | 2 | 0.034366 | |
| GO:0007596 | blood coagulation | 3 | 0.041412 | |
| GO:0045667 | regulation of osteoblast differentiation | 3 | 0.00816 | |
| Up-regulated genes | ||||
| GO:0009142 | nucleoside triphosphate biosynthetic process | 4 | 0.003512 | |
| GO:0006406 | mRNA export from nucleus | 3 | 0.004389 | |
| GO:0009144 | purine nucleoside triphosphate metabolic process | 4 | 0.005796 | |
| GO:0009260 | ribonucleotide biosynthetic process | 4 | 0.006063 | |
| GO:0006405 | RNA export from nucleus | 3 | 0.006715 | |
| GO:0009150 | purine ribonucleotide metabolic process | 4 | 0.00814 | |
| GO:0006164 | purine nucleotide biosynthetic process | 4 | 0.009852 | |
| GO:0015672 | monovalent inorganic cation transport | 5 | 0.014828 | |
| GO:0006644 | phospholipid metabolic process | 4 | 0.019213 | |
| GO:0034654 | nucleic acid biosynthetic process | 4 | 0.020019 | |
| GO:0034404 | nucleoside and nucleotide biosynthetic process | 4 | 0.020019 | |
| GO:0006665 | sphingolipid metabolic process | 3 | 0.021316 | |
| GO:0046784 | intronless viral mRNA export from host nucleus | 2 | 0.023835 | |
| GO:0006812 | cation transport | 6 | 0.024009 | |
| GO:0006643 | membrane lipid metabolic process | 3 | 0.024609 | |
| GO:0051028 | mRNA transport | 3 | 0.028097 | |
| GO:0006684 | sphingomyelin metabolic process | 2 | 0.03263 | |
| GO:0050657 | nucleic acid transport | 3 | 0.034322 | |
| GO:0050658 | RNA transport | 3 | 0.034322 | |
| GO:0019216 | regulation of lipid metabolic process | 3 | 0.044558 | |
| KEGG | ||||
| up-regulated genes | ||||
| hsa04920 | Adipocytokine signaling pathway | 3 | 0.039178 | |
| hsa04260 | Cardiac muscle contraction | 3 | 0.041574 | |
Count: enriched gene number in the GO category