Table 1.
Median and range of demographic information and clinical characteristics at baseline of 660 PPMI subjects
| Clinical variables Median (range) |
HC (N = 189) | PD (N = 412) | SWEDD (N = 59) | p value by Mann–Whitney test | |
|---|---|---|---|---|---|
| HC vs. PD | PD vs. SWEDD | ||||
| Age (years) | 62.05 (30.62–83.68) | 62.37 (33.5–84.88) | 63.25 (38.34–78.82) | 0.5002 | 0.4597 |
| Gender, F/M (% of male) | 69/120 (63 %) | 142/270 (66 %) | 23/36 (61 %) | 0.6263# | 0.4964# |
| Education (years) | 16 (8–24) | 16 (5–26) | 16 (8–24) | 0.0737 | 0.3263 |
| Age at onset (years) | – | 60.56 (25.37–83.01) | 60.74 (35.31–77.28) | – | 0.3911 |
| Duration of disease*, (months) | – | 4.22 (0.03–35.83) | 3.87 (0.53–37.00) | – | 0.9409 |
| CSF Hb >200 ng/mL, N (%) | 35 (19 %) | 84 (20 %) | 11 (19 %) | 0.5933# | 0.7548# |
| H&Y stage (N, %) | |||||
| Stage 0 | – | 0 | 0 | – | 0.1794# |
| Stage 1 | 179 (43.4 %) | 33 (55.9 %) | |||
| Stage 2 | 231 (56.1 %) | 26 (44.1 %)) | |||
| Stage 3–5 | 2 (0.5 %) | 0 | |||
| Missing | 0 (0 %) | 0 | |||
| MDS-UPDRS score | |||||
| Part I | 2 (0–17) | 5 (0–24) | 7 (0–27) | <0.001 | 0.0017 |
| Part II | 0 (0–6) | 5 (0–22) | 3 (0–25) | <0.001 | 0.2002 |
| Part III | 0 (0–13) | 20 (4–51) | 13 (2–42) | <0.001 | <0.0001 |
| Total | 3 (0–20) | 31 (7–72) | 26 (4–91) | <0.001 | 0.0093 |
| UPSIT score | 35 (11–40) | 22 (1–40) | 34 (12–39) | <0.001 | <0.0001 |
| HVLT-R score | |||||
| Total recall | 26 (15–35) | 25 (9–36) | 25 (13–31) | 0.0003 | 0.7998 |
| Delayed recall | 10 (2–12) | 9 (0–12) | 9 (0–12) | <0.001 | 0.8146 |
| Discr. recognition | 11 (−4 to 12) | 10(−4 to 12) | 10 (−2 to 12) | 0.0001 | 0.0408 |
| WMS-III LNS score | 11 (2–20) | 11(2–20) | 10 (4–15) | 0.2173 | 0.1192 |
| BJLO score | 14 (4–15) | 13 (5–15) | 13 (5–15) | 0.0602 | 0.9900 |
| Semantic fluency | 52 (22–80) | 48 (20–103) | 43 (23–81) | 0.0009 | 0.0226 |
| SDMT score | 47 (20–83) | 42 (7–82) | 43 (19–71) | <0.001 | 0.6167 |
| SCOPA-AUT score | 5 (0–20) | 8 (0–39) | 12 (3–44) | <0.001 | 0.0003 |
| MoCA | 28 (26–30) | 28 (17–30) | 28 (17–30) | <0.001 | 0.6791 |
| [MoCA <26, N] | [0, 0.0 %] | [91, 22.1 %] | [9, 15.3 %] | ||
| MSEADL | – | 90 (70–100) | 95 (75–100) | – | 0.0515 |
| STAI score | 54 (40–105) | 62 (40–137) | 65 (40–113) | <0.001 | 0.0875 |
| DAT scan (median uptake) | |||||
| Caudate median | 2.88 (1.32–5.2) | 1.95 (0.39–3.71) | 2.86 (1.38–4.01) | <0.001 | <0.0001 |
| Putamen median | 2.09 (0.64–3.89) | 0.79 (0.24–2.17) | 2.11 (0.78–3.01) | <0.001 | <0.0001 |
*
Disease duration was defined by (enrollment date–diagnosis date)
#
p values by Chi-square test