Table 2. Brain regions with significant group differences, corrected for multiple comparisons.

Group comparison	Finding	Brain region	Size	Talairach (x y z)	P-value*
CD with EIM vs. controls	Surface area ↑ in patients	Left rostral middle frontal gyrus	1171 mm2	-30.8 48.1 -0.2	0.0399
	LGI ↑ in patients	Left lingual gyrus, extending to precuneus, cuneus, PHG and isthmus cingulate	3632 mm2	-8.6 -75.9 7.1	0.0001
CD with EIM vs. CD without EIM	LGI ↑ in CD with EIM	Right rostral ACC, extending to superior frontal gyrus	1980 mm2	8.6 33.5 5.3	0.0191
	LGI ↓ in CD with EIM	Right insula	2903 mm2	32.1 10.6 10.3	0.0008

ACC, Anterior cingulate cortex; CD, Crohn’s Disease; EIM, Extraintestinal manifestation; GMV, Gray matter volume; LGI, Local gyrification index; PHG, Parahippocampal gyrus

* P-values as cluster-wise probability, vertex-wise analysis over the entire cortical mantle