Skip to main content
. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: J Neurochem. 2015 Sep 10;135(3):565–576. doi: 10.1111/jnc.13243

Figure 2. Central TGR5 agonism with betulinic acid in neuroprotective in AOM-treated mice.

Figure 2

(A) Neurological decline graph of mice treated with AOM and those treated with AOM + betulinic acid. Neurological score is a summation of 5 reflex scores and ataxia assessment as outlined in the methods with 12 having normal reflex scores and 0 having no reflex response. (B) Time to coma in hours following AOM administration in mice treated with AOM and those treated with AOM + betulinic acid. (C) cAMP concentrations in cortex homogenates from vehicle, AOM and AOM + betulinic acid-treated mice at coma. (D) H&E stained liver sections from vehicle, AOM and AOM + betulinic acid-treated mice at coma. * = p<0.05 compared to AOM.