Table 4. Common MAP and MAA Arcs and Mechanistic Genes in Tight Junction Pathway.
| Parent Gene | Parent Gene Description | Child cause | Childgene | MAP Norm. Arc Wt. | MAA Norm. Arc Wt. | Abs. Val. Difference | Correl. Direction | MAP 1st Mechanistic Time | MAP Parent Gene Score | MAP Child Gene Score | MAA 1st Mechanistic Time | MAA Parent Gene Score | MAA Child Gene Score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PARD3 | par-3 partitioning defective 3 homolog (C. elegans) | JAM3 | junctional adhesion molecule 3 | 0.27 | 0.56 | 0.29 | positive | t = 30 | 0 | 2.62 | t = 720 | -2.9 | 0 |
| ACTB | actin, beta | MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.2 | 0.38 | 0.18 | positive | t = 720 | 0 | 2.12 | t = 30 | -3.72 | 0 |
| CLDN7 | claudin 7 | MPDZ | multiple PDZ domain protein | -0.42 | -0.2 | 0.33 | negative | t = 60 | -3.17 | 0 | T = 480 | 2.4 | 0.81 |
| TJP1 | tight junction protein 1 | ACTG1 | actin, gamma 1 | 0.39 | 0.26 | 0.13 | positive | t = 60 | 0 | 2.04 | t = 60 | 0.74 | 2.57 |
| ACTG1 | actin, gamma 1 | MYH9 | myosin, heavy chain 9, non-muscle | 0.56 | 0.45 | 0.11 | positive | t = 60 | 2.04 | -1.37 | t = 60 | 2.57 | -1.55 |
| CDC42 | cell division cycle 42 (GTP binding protein, 25kDa) | PARD6B | par-6 partitioning defective 6 homolog beta (C. elegans) | 0.74 | 0.44 | 0.3 | positive | t = 720 | -3.53 | -0.81 | t = 240 | 2.53 | 0 |
| CLDN7 | claudin 7 | TJP3 | tight junction protein 3 (zona occludens 3) | 0.6 | 0.23 | 0.37 | positive | t = 60 | -3.17 | -1.81 | t = 480 | 2.4 | 0 |
| CDK4 | cyclin-dependent kinase 4 | CSDA | cold shock domain protein A | -0.36 | -0.2 | 0.16 | negative | t = 30 | -2.37 | -0.11 | t = 240 | 0 | -2.7 |
| CSNK2B | casein kinase 2, beta polypeptide | no child node | 0 | 0 | 0 | positive | t = 30 | -4.07 | 0 | t = 30 | -2.94 | 0 | |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | no child node | 0 | 00 | positive | t = 30 | -2.27 | 0 | t = 240 | 2.06 | 0 | ||
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 | no child node | 0 | 0 | 0 | positive | t = 60 | 2.08 | 0 | t = 720 | 2.47 | 0 | |
| PRKCZ | protein kinase C, zeta | no child node | 0 | 0 | 0 | positive | t = 240 | 2.72 | 0 | t = 30 | -2.75 | 0 | |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | no child node | 0 | 0 | 0 | positive | t = 30 | 2.03 | 0 | t = 240 | -2.36 | 0 |
Tight Junction Pathway Bayesian Model Interrogation Results of Gene-to-Gene Relationships and Mechanistic Genes found in common between the MAP and MAA conditions. See text for description of interrogation methods.