Table 5. Unique MAP Arcs and Mechanistic Genes in Tight Junction Pathway.
| Parent Gene | Parent Gene Description | Child Gene | Child Gene Description | MAP Norm. Arc Wt. | MAP Norm. Arc Wt. | Abs. Val. Difference | Correl. Direction | MAP 1st Mechanistic Time | MAP Parent Gene Score | MAP Child Gene Score | MAP Child Gene Score | MAP Child Gene Score | MAA Child Gene Score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACTN1 | actinin, alpha 1 | MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.21 | -0.03 | 0.24 | reverse | t = 30 | 0.71 | 2.65 | t = 60 | 0 | 1.99 |
| CLDN7 | claudin 7 | TJP2 | tight junction protein 2 (zona occludens 2) | -0.43 | 0.15 | 0.58 | reverse | t = 60 | -3.17 | 0 | t = 30 | -0.92 | 2.02 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | MLLT4 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | -0.41 | 0.1 | 0.51 | reverse | t = 60 | -0.41 | 2.17 | t = 480 | -0.51 | -3.1 |
| ACTG1 | MYH14 | MYH14 | myosin, heavy chain 14, non-muscle | 0.3 | 0.1 | 0.2 | positive | t = 30 | -0.98 | 2.75 | t = 60 | 2.57 | -0.23 |
| PRKCB | protein kinase C, beta | ACTB | actin, beta | 0.27 | 0.1 | 0.17 | positive | t = 720 | -2.69 | 0 | t = 30 | 0 | -3.72 |
| PARD3 | par-3 partitioning defective 3 homolog (C. elegans) | F11R | F11 receptor | -0.46 | -0.18 | 0.28 | negative | t = 30 | 0 | 1.99 | t = 720 | -2.9 | -1.05 |
| TJP1 | tight junction protein 1 | CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.48 | 0.3 | 0.18 | positive | t = 30 | 0 | -4.29 | 0 | -1.38 | |
| CLDN7 | CLDN7 | TJP1 | tight junction protein 1 | 0.23 | 0.03 | 0.2 | positive | t = 60 | -3.17 | 0 | t = 480 | 2.4 | -0.69 |
| CLDN7 | CLDN7 | CLDN7 | InaD-like (Drosophila) | 0.47 | 0.12 | 0.35 | positive | t = 60 | -3.17 | 0 | t = 480 | 2.4 | 0 |
| ACTG1 | actin, gamma 1 | MYL9 | myosin, light chain 9, regulatory | 0.3 | 0.13 | 0.17 | positive | t = 60 | 2.04 | 0 | t = 60 | 2.57 | 0 |
| ACTN3 | actinin, alpha 3 | MAGI2 | membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2-like | 0.21 | 0.07 | 0.14 | positive | t = 120 | 0 | 3.05 | t = 120 | 0 | 2.98 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.21 | 0.04 | 0.17 | positive | t = 30 | 2.62 | 0 | t = 30 | 2.02 | 0.6 |
| ACTG1 | actin, gamma 1 | MYL7 | myosin, light chain 7, regulatory | 0.38 | 0.17 | 0.21 | positive | t = 60 | 2.04 | -0.62 | t = 60 | 2.57 | -0.44 |
| PARD3 | par-3 partitioning defective 3 homolog (C. elegans) | IGSF5 | immunoglobulin superfamily, member 5 | 0.23 | 0.11 | 0.12 | positive | t = 720 | -2.71 | 0 | t = 720 | -2.9 | -0.53 |
| JAM3 | junctional adhesion molecule 3 | TJP1 | tight junction protein 1 | 0.29 | 0 | 0.29 | positive | t = 30 | 2.62 | 0 | 0 | 0 | |
| PRKCB | protein kinase C, beta | IGSF5 | immunoglobulin superfamily, member 5 | -0.24 | -0.13 | 0.11 | negative | t = 720 | -2.60 | 0 | 0.99 | -0.53 | |
| ACTN3 | actinin, alpha 3 | MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | -0.21 | 0.04 | 0.25 | reverse | t = 30 | 0 | 2.65 | t = 60 | 0 | 1.99 |
| PPP2R1A | protein phosphatase 2, regulatory subunit A, alpha | no child node | 0 | 0 | 0 | positive | t = 720 | 2.14 | 0 | 1.18 | 0 |
Tight Junction Pathway Bayesian Model Interrogation Results found unique to the MAP condition.