Table 2.

Results from the multiple regression analysis, all PD patients included

		Composite cognition		Executive/attention		Visuospatial function		Memory
Step	Predictor	Beta	P	Beta	p	Beta	p	Beta	p
1.	abeta42	0.071	0.189	0.068	0.211	0.067	0.220	0.020	0.719
	t-tau	−0.187	0.006	−0.216	0.001	−0.181	0.008	−0.128	0.062
	p-tau181	0.038	0.487	0.050	0.364	−0.008	0.891	0.028	0.618
	α-synuclein	0.165	0.014	0.174	0.009	0.161	0.016	0.136	0.044
2.	Abeta42	−0.015	0.752	−0.005	0.922	0.064	0.214	−0.055	0.259
	T-tau	−0.058	0.327	−0.084	0.172	−0.094	0.155	−0.023	0.715
	P-tau181	0.029	0.525	0.037	0.443	−0.026	0.612	0.022	0.657
	α-synuclein	0.132	0.019	0.137	0.020	0.118	0.058	0.109	0.068
	Gender (1 = F, 2 =M)	−0.251	<0.001	−0.153	<0.001	0.230	<0.001	−0.246	<0.001
	Age (in years)	−0.382	<0.001	−0.372	<0.001	−0.132	0.009	−0.323	<0.001
	Education (in years)	0.294	<0.001	0.294	<0.001	0.238	<0.001	0.256	<0.001
	UPDRS III total	−0.104	0.014	−0.062	0.158	−0.116	0.014	−0.085	0.057

Results from the multiple linear regression models of the effects of CSF markers on cognition in the PD patients. In step 1 only the CSF markers were included as predictors vs composite cognition and the cognitive domains as dependent variables. In step 2 potential confounding variables were added. Only patients without missing values were included in the analyses, n = 403 (5 excluded to due to extreme α-synuclein values, two due to missing p-tau, 4 due to missing t-tau results.). The reported beta-values are standardized.