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. Author manuscript; available in PMC: 2016 Sep 30.
Published in final edited form as: Oncogene. 2016 Mar 21;35(39):5191–5201. doi: 10.1038/onc.2016.56

Figure 5. Combinatorial MK-2206 and Progesterone treatments further decrease angiogenesis and proliferation in a conditional uterine PTENd/d mouse model.

Figure 5

A) Treatment overview of PTENd/d mice. B) Ratio of uterine weight to total body weight was measured for each of the Vehicle, MK-2206, P4, and MK+P4 treatment groups. C) H&E staining was performed on tissue sections from the Vehicle, MK-2206, P4, and MK+P4 treatment groups (10X magnification). D) CD31 staining was performed on tissue sections from the Vehicle, MK-2206, P4, and MK+P4 treatment groups (10X, 40X magnifications). CD31 staining was quantified using ImageJ. E) Ki67 staining was performed on tissue sections from the Vehicle, MK-2206, P4, and MK+P4 treatment groups (40X magnification). Ki67 staining was quantified using ImageJ.