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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Neurotoxicology. 2016 Mar 21;60:142–149. doi: 10.1016/j.neuro.2016.03.010

Fig. 5.

Fig. 5

Resting and use-dependent modification of rat Nav1.6 sodium channels expressed in HEK293 cells by pyrethroids (redrawn from data in He and Soderlund, 2011; He and Soderlund, 2016). (A) Effects of repeated 5-ms depolarizing prepulses delivered at 20 Hz on the extent of modification of sodium channels in HEK293 cells expressing Nav1.6+β1+β2 sodium channels by tefluthrin or deltamethrin. Values are the means of 6–19 determinations with different cells; bars show SE values larger than the data point symbols. (B) Effect of coexpression with the β1 and β2 subunits on the resting (0 prepulses) and use-dependent (100 prepulses) modification of Nav1.6 sodium channels by 10 µM deltamethrin. Values are means ± SE of 6–7 determinations with different cells; asterisk indicates a value for use-dependent modification significantly different from that for resting modification of the same channel (paired t-test, P < 0.05).