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Schematic diagram of HGF signaling pathways; A) Representative structures, cMET binding affinities (KD) and dimerization of HGF, NK1 (cMET agonists) and NK2 (cMET antagonists. B) HGF signaling pathways known to be involved in bone maturation; Ras-Raf1-MEK-ERK1/2 pathway, Ras-Raf1-MEK-p38 MAPK pathway, and PI3K/Akt pathway.
