Table 3.

Type and frequency of neonatal triggers, neonatal symptoms, and neonatal abnormal labs

Neonatal Triggers, Symptoms and Abnormal Labs	Frequency of Appearance
aNeonatal Triggers (37 subjects)
Poor Feeding	20
Prematurity (<37 weeks gestation)	15
Antibiotics	12
Respiratory distress	7
Infection/sepsis	5
Dehydration	4
Failure to thrive	2
Fever	2
Intralipids	2
Transient Tachypnea of the Newborn	2
Decreased oxygen saturation, fasted, loose stools, mild gastroesophageal reflux, poor growth, poor latch, vomiting, gavage feeding	1 each
bNeonatal Symptoms (28 subjects)
Lethargy	13
Distress	9
Tachypnea	8
Hypoglycemia	5
Hypothermia	3
Hypotonia	3
Irritability	3
Cardiomyopathy	2
Sleepy	2
Apnea, hepatomegaly, limp, metabolic acidosis, Echo: mild left hypertrophy, pallor, seizure, sweaty, tachycardia, temperature instability	1 each
cNeonatal Abnormal Labs (21 subjects)
Hypoglycemia	20
Elevated liver function tests	7
Metabolic acidosis	6
Elevated uric acid	3
Low Co2	2
Hyperuricemia	2
Elevated C reactive protein, abnormal carnitine level, abnormal CMP, elevated BUN, elevated CK, elevated creatinine, hyperammonemia, ketonuria, slight elevation ALT	1 each

^aneonatal complications and interventions suggestive of underlying health complications in the data determined by clinician authors as most likely to result in potential MCADD symptoms.

^bneonatal symptoms in the data determined by clinician authors as consistent with MCADD, many based on reports of symptoms manifested in individuals affected with MCADD. IBEM-IS data entry does not require clinician specification of whether a subject’s symptoms were ultimately attributed to or related to the particular IBEM diagnosis.

^cneonatal laboratory test abnormalities in the data determined by clinician authors to be of potential concern in the context of MCADD (excluding newborn screening and MCADD diagnostic biochemical and molecular test results).