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. Author manuscript; available in PMC: 2017 Oct 29.
Published in final edited form as: Neuroscience. 2016 Aug 17;335:151–169. doi: 10.1016/j.neuroscience.2016.08.019

Table 3.

RNA sequencing reveals 169 genes that significantly differ in expression between PDE11A KO versus WT littermates (sorted by KO vs. WT FDR P-value)

Gene ID KO vs. WT
 HT vs. WT
 KO vs. HT
logFC P-Value FDR P-value logFC P-Value FDR P-value logFC P-value FDR P-value
Xist 4.6819 2.351E–11 1.736E–07 0.8148 3.052E–01 9.998E–01 1.9335 4.048E–07 2.990E–03
Mylk −0.6646 3.077E–08 1.515E–04 −0.2890 1.542E–02 9.443E–01 −0.1878 1.368E–03 2.617E–01
Samd4 0.6946 5.943E–08 2.194E–04 0.4917 1.025E–04 4.619E–01 0.1015 1.120E–01 8.715E–01
Fgl2 −1.9915 2.400E–07 7.088E–04 −0.7670 3.958E–02 9.998E–01 −0.6122 1.233E–03 2.617E–01
Hivep1 1.1266 3.264E–07 8.036E–04 0.8016 2.502E–04 4.619E–01 0.1625 1.324E–01 8.955E–01
Syce2 −1.3233 5.799E–07 1.224E–03 −0.5006 4.899E–02 9.998E–01 −0.4113 1.245E–03 2.617E–01
Pitpnm3 0.8443 8.292E–07 1.531E–03 0.4902 3.295E–03 7.487E–01 0.1771 3.853E–02 7.123E–01
Hlf 0.7903 1.064E–06 1.746E–03 0.2144 1.765E–01 9.998E–01 0.2879 2.640E–04 1.950E–01
Satb1 0.8303 1.264E–06 1.867E–03 0.5077 2.779E–03 7.309E–01 0.1613 6.132E–02 7.703E–01
Asap1 0.8505 1.638E–06 2.199E–03 0.3569 3.840E–02 9.998E–01 0.2468 5.392E–03 4.525E–01
Unc13c 1.9464 2.114E–06 2.602E–03 1.2594 1.634E–03 7.120E–01 0.3435 8.163E–02 8.359E–01
Cacnb4 0.6627 2.398E–06 2.724E–03 0.3364 1.525E–02 9.443E–01 0.1631 1.999E–02 6.357E–01
Mtcl1 0.8188 2.949E–06 3.046E–03 0.2353 1.849E–01 9.998E–01 0.2917 9.939E–04 2.617E–01
Fam26e −0.6501 3.096E–06 3.046E–03 −0.2762 4.846E–02 9.998E–01 −0.1869 8.562E–03 5.038E–01
Hecw1 0.7093 3.300E–06 3.046E–03 0.3463 2.109E–02 9.852E–01 0.1815 1.467E–02 5.640E–01
St3gal1 1.0880 3.808E–06 3.309E–03 0.6929 2.668E–03 7.297E–01 0.1976 8.500E–02 8.392E–01
Cobl 1.3253 5.535E–06 4.542E–03 1.0592 2.278E–04 4.619E–01 0.1331 3.443E–01 9.457E–01
Nbl1 −0.7475 6.227E–06 4.812E–03 −0.4266 7.894E–03 8.388E–01 −0.1604 5.065E–02 7.449E–01
Grm8 1.2196 6.516E–06 4.812E–03 0.8843 9.596E–04 6.450E–01 0.1677 2.027E–01 9.260E–01
Etl4 0.7987 7.032E–06 4.946E–03 0.5497 1.983E–03 7.120E–01 0.1245 1.608E–01 9.132E–01
Rab26 −0.6809 7.532E–06 5.057E–03 −0.2208 1.347E–01 9.998E–01 −0.2301 2.150E–03 3.125E–01
Rora 0.7188 7.926E–06 5.090E–03 0.4800 2.485E–03 7.120E–01 0.1194 1.270E–01 8.897E–01
Mlip 0.6955 1.174E–05 7.223E–03 0.5119 7.089E–04 5.847E–01 0.0918 2.473E–01 9.415E–01
Il1rapl2 1.3039 1.480E–05 8.743E–03 0.6506 3.221E–02 9.998E–01 0.3267 2.532E–02 6.812E–01
Plcb4 0.8478 1.581E–05 8.979E–03 0.5576 3.578E–03 7.738E–01 0.1451 1.348E–01 8.971E–01
RP24–490B17.1 2.0479 1.765E–05 9.435E–03 0.8881 6.392E–02 9.998E–01 0.5799 1.327E–02 5.401E–01
Cntn4 0.8808 1.840E–05 9.435E–03 0.5997 3.201E–03 7.471E–01 0.1406 1.486E–01 9.053E–01
Vwc2l 1.8754 1.853E–05 9.435E–03 1.3651 1.367E–03 7.120E–01 0.2551 2.188E–01 9.322E–01
Zdhhc22 1.3832 2.075E–05 1.021E–02 0.6864 3.144E–02 9.998E–01 0.3484 2.750E–02 6.839E–01
Frmd7 −1.1582 2.399E–05 1.074E–02 −0.5211 4.737E–02 9.998E–01 −0.3186 2.140E–02 6.517E–01
Pamr1 0.9322 2.317E–05 1.074E–02 0.5266 1.588E–02 9.443E–01 0.2028 6.407E–02 7.763E–01
Dlg1 0.4058 2.361E–05 1.074E–02 0.2297 1.534E–02 9.443E–01 0.0881 6.472E–02 7.763E–01
Cpne7 −0.9417 2.905E–05 1.226E–02 −0.2759 1.905E–01 9.998E–01 −0.3329 2.800E–03 3.504E–01
Nr4a2 0.9161 2.828E–05 1.226E–02 0.7585 6.396E–04 5.847E–01 0.0788 4.777E–01 9.518E–01
Fut9 0.6358 3.079E–05 1.263E–02 0.3092 4.054E–02 9.998E–01 0.1633 2.764E–02 6.839E–01
Pknox2 0.5421 3.193E–05 1.275E–02 0.1613 1.994E–01 9.998E–01 0.1904 3.439E–03 3.681E–01
Igfbp3 −0.8821 3.446E–05 1.339E–02 0.0503 7.989E–01 9.998E–01 −0.4662 9.618E–06 4.735E–02
Deptor 1.1437 3.608E–05 1.366E–02 0.7056 1.015E–02 8.766E–01 0.2190 1.002E–01 8.567E–01
Camk2g 0.4572 3.942E–05 1.399E–02 0.0855 4.258E–01 9.998E–01 0.1858 8.338E–04 2.512E–01
Astn2 0.5271 3.796E–05 1.399E–02 0.1916 1.256E–01 9.998E–01 0.1677 8.933E–03 5.095E–01
Lnp 0.4311 3.977E–05 1.399E–02 0.3909 2.466E–04 4.619E–01 0.0201 7.065E–01 9.797E–01
Adra1d −0.8237 4.383E–05 1.407E–02 −0.3748 5.364E–02 9.998E–01 −0.2245 2.522E–02 6.812E–01
Smad6 −1.6239 4.283E–05 1.407E–02 −0.9034 2.135E–02 9.852E–01 −0.3603 6.840E–02 7.885E–01
Chrna4 0.8001 4.221E–05 1.407E–02 0.4968 1.161E–02 9.421E–01 0.1516 1.176E–01 8.771E–01
Sowahb 1.4828 4.328E–05 1.407E–02 1.0883 2.371E–03 7.120E–01 0.1973 2.776E–01 9.441E–01
Tshz3 1.3431 4.644E–05 1.459E–02 0.6382 4.970E–02 9.998E–01 0.3525 2.655E–02 6.812E–01
Rnf128 −0.5481 5.331E–05 1.637E–02 −0.1518 2.552E–01 9.998E–01 −0.1981 2.978E–03 3.605E–01
Gm23935 −1.2578 5.431E–05 1.637E–02 −0.4726 1.597E–01 9.998E–01 −0.3926 1.825E–02 6.130E–01
Slc17a6 1.4644 5.748E–05 1.687E–v02 0.8239 1.942E–02 9.723E–01 0.3202 7.196E–02 8.035E–01
Pth1r 1.0572 5.825E–05 1.687E–02 0.8738 6.847E–04 5.847E–01 0.0917 4.763E–01 9.518E–01
Epha10 0.5337 5.999E–05 1.698E–02 0.2302 8.915E–02 9.998E–01 0.1518 2.389E–02 6.784E–01
Hspa1b −0.9499 6.174E–05 1.698E–02 −0.4208 7.725E–02 9.998E–01 −0.2646 2.445E–02 6.804E–01
Osbpl3 0.6298 6.207E–05 1.698E–02 0.3116 4.510E–02 9.998E–01 0.1591 4.309E–02 7.265E–01
Tusc1 −0.8527 6.390E–05 1.716E–02 −0.1130 5.845E–01 9.998E–01 −0.3699 5.334E–04 2.462E–01
Ubac2 −0.3748 6.566E–05 1.732E–02 −0.2280 1.552E–02 9.443E–01 −0.0734 1.204E–01 8.771E–01
Nova1 0.6060 6.856E–05 1.777E–02 0.2648 7.041E–02 9.998E–01 0.1706 2.498E–02 6.812E–01
Ptgds −1.6596 7.009E–05 1.785E–02 −0.4602 2.558E–01 9.998E–01 −0.5997 2.959E–03 3.605E–01
Cntnap5a 0.7787 7.409E–05 1.797E–02 0.3909 4.037E–02 9.998E–01 0.1939 4.467E–02 7.329E–01
Cit 0.9118 7.371E–05 1.797E–02 0.6235 6.443E–03 8.209E–01 0.1441 2.035E–01 9.263E–01
Slc20a1 0.3071 7.478E–05 1.797E–02 0.2245 4.194E–03 7.738E–01 0.0413 2.905E–01 9.443E–01
Lrrtm3 0.8080 7.542E–05 1.797E–02 0.8092 6.359E–05 4.619E–01 −0.0006 9.949E–01 9.994E–01
Fam53b 0.5043 7.863E–05 1.834E–02 0.0684 5.987E–01 9.998E–01 0.2180 7.599E–04 2.512E–01
Cdon 0.7665 7.947E–05 1.834Ex–02 0.3634 6.201E–02 9.998E–01 0.2015 3.872E–02 7.130E–01
R3hdm2 0.3424 8.228E–05 1.870E–02 0.1582 6.914E–02 9.998E–01 0.0921 3.418E–02 7.000E–01
Rprml −0.8683 8.893E–05 1.976E–02 −0.2619 2.362E–01 9.998E–01 −0.3032 6.772E–03 4.713E–01
Gm22405 −2.2935 9.097E–05 1.976E–02 −1.4109 1.486E–02 9.443E–01 −0.4413 1.328E–01 8.955E–01
Fgd2 1.2255 9.010E–05 1.976E–02 0.8777 4.495E–03 7.738E–01 0.1739 2.363E–01 9.398E–01
Zfp365 0.3791 9.500E–05 1.976E–02 0.0822 3.955E–01 9.998E–01 0.1485 1.970E–03 2.984E–01
Obscn 0.9565 9.380E–05 1.976E–02 0.5057 3.871E–02 9.998E–01 0.2254 6.629E–02 7.829E–01
Gm28370 0.6501 9.390E–05 1.976E–02 0.4202 1.352E–02 9.443E–01 0.1150 1.574E–01 9.128E–01
Agps 0.3853 1.036E–04 2.125E–02 0.1543 1.258E–01 9.998E–01 0.1155 2.106E–02 6.480E–01
Snca −0.4367 1.050E–04 2.125E–02 −0.2042 6.800E–02 9.998E–01 −0.1162 3.756E–02 7.077E–01
Rcan2 0.4698 1.078E–04 2.151E–02 0.3143 9.596E–03 8.688E–01 0.0777 1.996E–01 9.255E–01
Galnt13v 0.6550 1.108E–04 2.183E–02 0.2291 1.673E–01 9.998E–01 0.2130 1.025E–02 5.271E–01
Kdm5d −4.6329 1.151E–04 2.208E–02 −1.3754 6.847E–02 9.998E–01 −1.6287 1.937E–02 6.282E–01
B930095G15Rik 0.6217 1.147E–04 2.208E–02 0.4885 3.026E–03 7.406E–01 0.0666 4.017E–01 9.478E–01
Stard5 −0.5076 1.270E–04 2.406E–02 −0.3388 1.051E–02 8.974E–01 −0.0844 2.051E–01 9.272E–01
Olfm3 0.6911 1.309E–04 2.448E–02 0.6636 2.247E–04 4.619E–01 0.0138 8.778E–01 9.924E–01
Tshz2 1.8146 1.336E–04 2.466E–02 0.8524 6.725E–02 9.998E–01 0.4811 3.457E–02 7.013E–01
Rxfp1 1.7468 1.420E–04 2.527E–02 0.6832 1.310E–01 9.998E–01 0.5318 1.641E–02 5.801E–01
Satb2 1.2285 1.390E–04 2.527E–02 0.6804 3.054E–02 9.998E–01 0.2740 8.687E–02 8.402E–01
Yam1 −1.8381 1.415E–04 2.527E–02 −1.8508 1.697E–04 4.619E–01 0.0064 9.785E–01 9.989E–01
Dcaf12l2 −0.9540 1.438E–04 2.529E–02 −0.2825 2.562E–01 9.998E–01 −0.3358 7.761E–03 4.838E–01
Kcnab3 0.7636 1.541E–04 2.677E–02 0.4629 2.285E–02 9.959E–01 0.1503 1.469E–01 9.053E–01
Gm11914 −0.7652 1.648E–04 2.750E–02 −0.0130 9.484E–01 9.998E–01 −0.3761 2.296E–04 1.785E–01
Tesc −0.6218 1.652E–04 2.750E–02 −0.2546 1.118E–01 9.998E–01 −0.1836 2.571E–02 6.812E–01
Slc35e2 0.4057 1.625E–04 2.750E–02 0.2064 5.572E–02 9.998E–01 0.0996 6.372E–02 7.763E–01
Hkdc1 0.8737 1.657E–04 2.750E–02 0.5539 1.801E–02 9.498E–01 0.1599 1.720E–01 9.210E–01
Rnf217 0.5521 1.696E–04 2.784E–02 0.5010 5.547E–04 5.847E–01 0.0255 7.228E–01 9.797E–01
Dcdc2a −0.6627 1.716E–04 2.785E–02 −0.2704 1.225E–01 9.998E–01 −0.1962 2.578E–02 6.812E–01
Calcrl −0.5534 1.910E–04 2.794E–02 −0.0688 6.409E–01 9.998E–01 −0.2423 6.780E–04 2.512E–01
Rph3a 0.5848 1.841E–04 2.794E–02 0.0880 5.685E–01 9.998E–01 0.2484 1.260E–03 2.617E–01
Tacc1 0.4630 1.885E–04 2.794E–02 0.1262 3.085E–01 9.998E–01 0.1684 6.032E–03 4.713E–01
Fcgbp −1.2194 1.743E–04 2.794E–02 −0.3520 2.712E–01 9.998E–01 −0.4337 7.536E–03 4.829E–01
Grm2 0.9173 1.909E–04 2.794E–02 0.3328 1.632E–01 9.998E–01 0.2922 1.665E–02 5.801E–01
Syt2 1.1424 1.802E–04 2.794E–02 0.4946 9.704E–02 9.998E–01 0.3239 3.012E–02 6.878E–01
Plxdc1 1.2835 1.835E–04 2.794E–02 0.7993 1.605E–02 9.443E–01 0.2421 1.538E–01 9.084E–01
Mcc 0.5805 1.899E–04 2.794E–02 0.4434 4.223E–03 7.738E–01 0.0685 3.637E–01 9.457E–01
Dsc3 2.9992 1.850E–04 2.794E–02 2.3767 2.806E–03 7.309E–01 0.3113 4.064E–01 9.479E–01
Brinp3 0.7647 1.800E–04 2.794E–02 0.6185 2.243E–03 7.120E–01 0.0731 4.726E–01 9.510E–01
Epha5 0.6288 1.943E–04 2.813E–02 0.2785 9.477E–02 9.998E–01 0.1751 3.901E–02 7.130E–01
Grik3 0.9567 1.978E–04 2.837E–02 0.6005 1.851E–02 9.518E–01 0.1781 1.559E–01 9.089E–01
Nxph3 1.2644 2.091E–04 2.970E–02 0.8348 1.607E–02 9.443E–01 0.2148 2.023E–01 9.256E–01
Smarcd3 −0.4134 2.275E–04 3.171E–02 −0.1088 3.258E–01 9.998E–01 −0.1523 6.890E–03 4.713E–01
Scn4b 1.3640 2.263E–04 3.171E–02 0.6231 8.663E–02 9.998E–01 0.3705 4.042E–02 7.215E–01
Grb7 1.9920 2.303E–04 3.179E–02 1.4475 6.829E–03 8.209E–01 0.2723 2.977E–01 9.443E–01
Crym −0.5688 2.336E–04 3.195E–02 −0.3365 2.362E–02 9.998E–01 −0.1162 1.241E–01 8.818E–01
Tbc1d30 0.4939 2.387E–04 3.235E–02 0.2748 3.946E–02 9.998E–01 0.1095 1.030E–01 8.576E–01
Cbln2 0.9211 2.441E–04 3.248E–02 0.4791 5.943E–02 9.998E–01 0.2210 8.262E–02 8.359E–01
Wdr83 −0.4093 2.432E–04 3.248E–02 −0.2675 1.656E–02 9.498E–01 80.0709 2.002E–01 9.255E–01
Cecr2 0.6876 2.490E–04 3.284E–02 0.0912 6.358E–01 9.998E–01 0.2982 1.826E–03 2.900E–01
Vipr1 0.5246 2.558E–04 3.314E–02 0.1278 3.893E–01 9.998E–01 0.1984 7.324E–03 4.822E–01
Gm27177 4.2839 2.545E–04 3.314E–02 2.8819 1.195E–02 9.425E–01 0.7010 1.897E–01 9.218E–01
Mgp −1.1996 2.700E–04 3.468E–02 −0.8580 8.336E–03 8.610E–01 −0.1708 2.776E–01 9.441E–01
Limk2 0.2955 2.756E–04 3.509E–02 0.1775 3.353E–02 9.998E–01 0.0590 1.560E–01 9.089E–01
Fam217b 0.2971 2.896E–04 3.538E–02 0.1064 1.954E–01 9.998E–01 0.0953 1.996E–02 6.357E–01
Zdhhc14 −0.4323 2.898E–04 3.538E–02 −0.1936 9.898E–02 9.998E–01 −0.1194 4.400E–02 7.328E–01
Ttc30b −0.3918 2.893E–04 3.538E–02 −0.1829 9.113E–02 9.998E–01 −0.1044 5.473E–02 7.501E–01
Cacng3 0.4936 2.898E–04 3.538E–02 0.2444 6.276E–02 9.998E–01 0.1246 6.737E–02 7.843E–01
Kcnt1 0.6121 2.888E–04 3.538E–02 0.4703 6.106E–03 8.209E–01 0.0709 4.073E–01 9.479E–01
Cdh7 0.7944 2.973E–04 3.599E–02 0.6049 5.484E–03 8.100E–01 0.0948 3.819E–01 9.457E–01
Sh3bgrl −0.3908 3.202E–04 3.845E–02 −0.2139 4.429E–02 9.998E–01 −0.0885 1.032E–01 8.576E–01
Tyro3 0.3389 3.257E–04 3.880E–02 0.0525 5.711E–01 9.998E–01 0.1432 2.374E–03 3.217E–01
Ank1 0.6262 3.296E–04 3.894E–02 0.3612 4.014E–02 9.998E–01 0.1325 1.306E–01 8.922E–01
Rhobtb2 0.4320 3.418E–04 4.006E–02 0.2404 3.852E–02 9.998E–01 0.0958 1.074E–01 8.639E–01
Kif5a 0.3307 3.524E–04 4.066E–02 0.1806 5.095E–02 9.998E–01 0.0750 1.044E–01 8.586E–01
Gm5639 −1.0324 3.520E–04 4.066E–02 −0.7001 1.528E–02 9.443E–01 −0.1661 2.621E–01 9.423E–01
Gatsl2 0.4026 3.590E–04 4.110E–02 0.1782 1.159E–01 9.998E–01 0.1122 4.651E–02 7.355E–01
Arhgef10l 0.5565 3.676E–04 4.141E–02 0.2019 1.723E–01 9.998E–01 0.1773 2.326E–02 6.713E–01
Trim66 0.8119 3.701E–04 4.141E–02 0.5932 8.757E–03 8.649E–01 0.1094 3.261E–01 9.457E–01
Pcdh15 0.9567 3.665E–04 4.141E–02 0.9113 7.126E–04 5.847E–01 0.0227 8.649E–01 9.921E–01
Lama3 1.1681 3.737E–04 4.150E–02 0.5850 7.442E–02 9.998E–01 0.2916 7.112E–02 8.013E–01
Stk3 −0.3788 3.809E–04 4.179E–02 −0.0391 6.976E–01 9.998E–01 −0.1698 1.468E–03 2.617E–01
Prss23 −0.7360 3.820E–04 4.179E–02 −0.5581 6.054E–03 8.209E–01 −0.0889 3.671E–01 9.457E–01
G8m24447 −1.3571 3.849E–04 4.180E–02 −0.9883 1.243E–02 9.425E–01 −0.1844 3.447E–01 9.457E–01
Arap2 0.5580 3.929E–04 4.236E–02 0.2518 1.097E–01 9.998E–01 0.1531 5.159E–02 7.478E–01
Pi15 −1.0084 3.990E–04 4.270E–02 −0.1340 6.215E–01 9.998E–01 −0.4372 2.229E–03 3.149E–01
Galk2 −0.3509 4.069E–04 4.317E–02 −0.0144 8.856E–01 9.998E–01 −0.1682 8.177E–04 2.512E–01
Rapgef3 0.4784 4.092E–04 4.317E–02 0.2501 6.167E–02 9.998E–01 0.1142 8.934E–02 8.430E–01
Arhgef15 0.6324 4.133E–04 4.329E–02 0.3132 7.582E–02 9.998E–01 0.1596 6.946E–02 7.918E–01
Sytl2 0.5686 4.203E–04 4.372E–02 0.2429 1.333E–01 9.998E–01 0.1629 4.235E–02 7.249E–01
Zmat4 0.5322 4.252E–04 4.392E–02 0.1010 4.954E–01 9.998E–01 0.2156 3.267E–03 3.676E–01
Pik3c2b 0.6788 4.317E–04 4.398E–02 0.2323 2.393E–01 9.998E–01 0.2232 2.332E–02 6.713E–01
Rgs6 0.9177 4.299E–04 4.398E–02 0.5679 2.817E–02 9.998E–01 0.1749 1.717E–01 9.210E–01
Cacna2d2 0.4855 4.381E–04 4.432E–02 0.3532 9.762E–03 8.688E–01 0.0662 3.401E–01 9.457E–01
Epb4.1 0.7239 4.545E–04 4.532E–02 0.1620 4.260E–01 9.998E–01 0.2810 5.182E–03 4.424E–01
Dock3 0.7209 4.613E–04 4.532E–02 0.2911 1.533E–01 9.998E–01 0.2149 3.668E–02 7.063E–01
Slc8a3 0.6069 4.511E–04 4.532E–02 0.2673 1.186E–01 9.998E–01 0.1698 4.152E–02 7.240E–01
Ncald 0.5018 4.622E–04 4.532E–02 0.2284 1.039E–01 9.998E–01 0.1367 4.919E–02 7.420E–01
Gm5616 −0.4293 4.634E–04 4.532E–02 −0.2619 3.185E–02 9.998E–01 −0.0837 1.756E–01 9.210E–01
Tmem180 −0.3773 4.738E–04 4.604E–02 −0.1906 7.419E–02 9.998E–01 −0.0933 8.470E–02 8.384E–01
Agap1 0.3895 4.858E–04 4.607E–02 0.1665 1.329E–01 9.998E–01 0.1115 4.560E–02 7.348E–01
Map3k9 0.7193 4.847E–04 4.607E–02 0.3765 6.769E–02 9.998E–01 0.1714 9.319E–02 8.465E–01
Atp10b 1.2795 4.897E–04 4.607E–02 0.6771 6.617E–02 9.998E–01 0.3012 1.031E–01 8.576E–01
Arhgap32 0.5381 4.873E–04 4.607E–02 0.3709 1.611E–02 9.443E–01 0.0836 2.780E–01 9.442E–01
Mapk6 0.4079 4.857E–04 4.607E–02 0.3133 6.890E–03 8.209E–01 0.0473 4.179E–01 9.479E–01
Fibcd1 −0.8530 4.940E–04 4.618E–02 −0.4837 5.282E–02 9.998E–01 −0.1847 1.484E–01 9.053E–01
Cpne2 −1.2501 5.141E–04 4.757E–02 −0.1021 7.650E–01 9.998E–01 −0.5740 1.408E–03 2.617E–01
Gm6788 −0.5516 5.250E–04 4.757E–02 −0.0535 7.368E–01 9.998E–01 −0.2490 1.715E–03 2.814E–01
Gst8m6 −0.5525 5.179E–04 4.757E–02 −0.1977 2.082E–01 9.998E–01 −0.1774 2.568E–02 6.812E–01
Nrros −0.5870 5.241E–04 4.757E–02 −0.3482 4.270E–02 9.998E–01 −0.1194 1.722E–01 9.210E–01
Gucy1a3 0.5850 5.231E–04 4.757E–02 0.5019 2.507E–03 7.120E–01 0.0416 6.213E–01 9.711E–01
Dock10 0.6370 5.379E–04 4.786E–02 0.0765 6.802E–01 9.998E–01 0.2802 2.561E–03 3.328E–01
Ssbp4 −0.4606 5.317E–04 4.786E–02 −0.1781 1.727E–01 9.998E–01 −0.1412 3.273E–02 6.915E–01
Wwox 0.4364 5.376E–04 4.786E–02 0.3074 1.511E–02 9.443E–01 0.0645 3.053E–01 9.455E–01
Syt6 −0.7500 5.528E–04 4.889E–02 −0.0377 8.615E–01 9.998E–01 −0.3561 1.080E–03 2.617E–01
Nlk 0.3939 5.674E–04 4.939E–02 0.1694 1.339E–01 9.998E–01 0.1122 4.566E–02 7.348E–01
Prrg3 0.6091 5.649E–04 4.939E–02 0.4106 1.976E–02 9.762E–01 0.0992 2.529E–01 9.423E–01
Orai3 −0.3671 5.684E–04 4.939E–02 −0.2533 1.729E–02 9.498E–01 −0.0569 2.767E–01 9.441E–01

KO–PDE11A knockout; WT–PDE11A wild-type; HT–PDE11A heterozygous mouse.

Note: In the HT vs. WT and KO vs. HT analyses, no genes were significant at the level of the whole genome (i.e., all FDR-corrected P-values were >0.05). That said, P-values for a number of genes reached significance in both analyses when the stricter Bonferroni correction was applied but limited to the number of genes within this specific gene set (i.e., 0.05/169 = P < 0.00029; shown in bold).