Table 4.
Pathway analyses following RNA sequencing of VHIPP from male and female adult PDE11A wild-type versus knockout mice
| GO_id | Term | # Genes | p-value_fdr |
|---|---|---|---|
| KEGG pathways | |||
| 4261 | Adrenergic signaling in cardiomyocytes | 8 | 1.74E–03 |
| 4921 | Oxytocin signaling pathway | 7 | 1.37E–02 |
| 4080 | Neuroactive ligand-receptor interaction | 9 | 1.37E–02 |
| GO biological processes | |||
| G0:0007268 | Synaptic transmission | 12 | 2.97E–02 |
| G0:0051239 | Regulation of multicellular organismal process | 35 | 2.97E–02 |
| G0:0030001 | Metal ion transport | 13 | 2.97E–02 |
| G0:0007196 | Adenylate cyclase-inhibiting G-protein-coupled glutamate receptor signaling pathway | 3 | 3.07E–02 |
| GO:0006812 | Cation transport | 15 | 3.07E–02 |
| G0:0051056 | Regulation of small gtpase-mediated signal transduction | 12 | 3.07E–02 |
| GO:0065008 | Regulation of biological quality | 36 | 3.46E–02 |
| G0:0006816 | Calcium ion transport | 8 | 4.21E–02 |
| GO Cellular componenets | |||
| G0:0045202 | Synapse | 22 | 2.83E–06 |
| G0:0042995 | Cell projection | 34 | 2.20E–05 |
| G0:0097458 | Neuron part | 25 | 4.47E–04 |
| G0:0044456 | Synapse part | 15 | 1.05E–03 |
| G0:0005886 | Plasma membrane | 49 | 1.42E–03 |
| G0:0043005 | Neuron projection | 21 | 1.42E–03 |
| G0:0034702 | Ion channel complex | 10 | 1.98E–03 |
| G0:1902495 | Transmembrane transporter complex | 10 | 2.98E–03 |
| G0:0071944 | Cell periphery | 48 | 2.98E–03 |
| G0:1990351 | Transporter complex | 10 | 2.98E–03 |
| G0:0008328 | Ionotropic glutamate receptor complex | 5 | 4.10E–03 |
| G0:0005623 | Cell | 107 | 7.23E–03 |
| G0:0005622 | Intracellular | 96 | 8.78E–03 |
| G0:0044464 | Cell part | 106 | 9.25E–03 |
| G0:0043235 | Receptor complex | 9 | 1.50E–02 |
| G0:0030054 | Cell junction | 19 | 1.95E–02 |
| G0:0097060 | Synaptic membrane | 8 | 3.84E–02 |
| G0:0042734 | Presynaptic membrane | 4 | 4.52E–02 |
| G0:0044424 | Intracellular part | 92 | 4.57E–02 |
| GO molecular functions | |||
| G0:0043167 | Ion binding | 61 | 3.93E–03 |
| G0:0005543 | Phospholipid binding | 11 | 1.70E–02 |
| G0:0001640 | Adenylate cyclase inhibiting G-protein-coupled glutamate receptor activity | 3 | 1.70E–02 |
| G0:0008289 | Lipid binding | 14 | 1.70E–02 |
| G0:0043169 | Cation binding | 43 | 1.70E–02 |
| G0:0030276 | Clathrin binding | 5 | 1.70E–02 |
| G0:0046872 | Metal ion binding | 42 | 1.79E–02 |
| G0:0098772 | Molecular function regulator | 19 | 2.05E–02 |
| G0:0005261 | Cation channel activity | 9 | 2.73E–02 |
| G0:0005089 | Rho guanyl-nucleotide exchange factor activity | 5 | 2.74E–02 |
| G0:0005088 | Ras guanyl-nucleotide exchange factor activity | 6 | 3.99E–02 |
Pathway analyses conducted using STRING 10.0. n = 7/genotype. VHIPP–ventral hippocampal formation.
Note: 5/8 genes included in the “Adrenergic signaling in cardiomyocytes” pathway are represented in the “Oxytocin” pathway.