Figure 3.

Combinatorial-iChIP Signal Is a Quantitative Measure

(A) Schematic description of the constraints relating the abundances of individual marks at a location to the co-abundance of the dual marks at the same location. If combinatorial-iChIP signal is quantitative, then it should obey these constraints (up to a multiplicative constant).

(B–D) Comparison of the individual ChIP of H3K36me3 and H3K79me3 to their combinatorial signal. Each panel interrogates one constraint (dashed lines). Occupancy levels are as assigned by the model’s transformation of the data (Experimental Procedures).

(E) Comparison of observed combinatorial signal against the value expected based on independence between the two individual marks. See also Figure S3.