Fig. 7.

Bcl-2 inhibitor augments the inhibitory effects of cisplatin in tongue cancer cells in vivo. a Combination of ABT-199 with cisplatin inhibits much more growth of tongue cancer xenograft mouse model than single drug alone. ABT-199 and cisplatin inhibits growth of tumor derived from SCC-9 cells as a single agent. Combination of ABT-199 with cisplatin completely arrests tumor growth throughout the duration of treatment. There are 10 mice in each group. Data were presented as mean ± SEM. *p < 0.05, compared to single arm treatment. b Representative photos of H&E staining. Increased cell death shown by cytoplasmic swelling, vacuolization or disintegration were observed in combination group compared to control or single treatment group. Scale bar presents 50 μM