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. 2016 Sep 22;10:218. doi: 10.3389/fncel.2016.00218

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Copyright © 2016 Arnold, Cross, Singleton, Zlatic, Chapleau, Mullin, Rolle, Moore, Theibert, Pozzo-Miller, Faundez and Larimore.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Null mutations of Mecp2 reduce mRNA but not protein levels of AGAP1. (A) Relative mRNA levels in the hippocampus for WT (gray) and Mecp2^−/y (green). Negative control Vamp2 (V2) and positive controls Mecp2. No significant difference was measured for mRNA levels of V2. In Mecp2^−/y, there was a significant decrease of Mecp2 (p = 0.005). AGAP1 mRNA levels were significantly decreased in Mecp2^−/y (p = 0.003). (B) Micrographs of the dentate gyrus at 20× for WT and Mecp2^−/y. In red is synaptophysin and in green is AGAP1. (C) Quantification of the intensity levels of AGAP1 compared to synaptophysin in Mecp2^−/y mice. AGAP1 intensity levels were not significantly decreased in Mecp2^−/y (p = 0.6).