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. 2016 Sep 22;10:434. doi: 10.3389/fnins.2016.00434

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Copyright © 2016 Nimitvilai, You, Arora, McElvain, Vandegrift, Brodie and Woodward.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of toluene in the presence of ZD7288 and GABA antagonists. Toluene (400 or 800 μM) was tested in the presence of ZD7288 (20 μM) (gray), ZD7288 plus 100 μM barium (blue), or ZD7288 and a combination of GABA antagonists [GABA-A antagonist bicuculline (10 μM) and GABA-B antagonist CGP35348 (10 μM); red]. With ZD7288 in the medium, there was an apparent blockade of the excitatory effects of toluene. This blockade of toluene-induced excitation was not reversed by the addition of barium to the medium. In the presence of ZD7288 and GABA antagonists, there was a significant restoration of the toluene-induced excitation (P < 0.001; two-way Anova, F_{(2, 40)} = 9.24; ^*P < 0.05).