Figure 1.

Experimental schedule for METH and ethanol administration. Rats were administered oral gavage of either water or ethanol (6 g/kg) for 7 days followed by either METH (10 mg/kg i.p., every 2 h for 4 times) or saline vehicle (i.p.). After completion of the four METH injections, rats were randomly assigned to receive either CEF (200 mg/kg i.p.) or saline vehicle (i.p.) for 2 days. Control and treated rats were then quickly euthanized (72 and 48 h following last water/ethanol and saline/METH administration, respectively) by CO2 inhalation and rapidly decapitated.