Table 1.
Tissue distribution of [11C]MA2 in control mice at 2 and 60 min post injection (n = 4 per time point).
| [11C]MA2 | % IDa | SUVb | ||
|---|---|---|---|---|
| 2 min | 60 min | 2 min | 60 min | |
| Bladder + urine | 0.2 ± 0.1 | 4.5 ± 1.0 | – | – |
| Kidneys | 8.3 ± 1.6 | 1.0 ± 0.3 | 5.1 ± 0.7 | 0.6 ± 0.1 |
| Liver | 28.3 ± 2.9 | 9.1 ± 3.0 | 6.0 ± 0.1 | 2.0 ± 0.5 |
| Spleen | 0.5 ± 0.2 | 0.03 ± 0.01 | 2.0 ± 0.2 | 0.2 ± 0.0 |
| Pancreas | 1.6 ± 0.8 | 0.2 ± 0.1 | 2.2 ± 1.0 | 0.3 ± 0.0 |
| Lungs | 1.4 ± 0.3 | 0.1 ± 0.0 | 2.3 ± 0.4 | 0.2 ± 0.0 |
| Heart | 1.4 ± 0.4 | 0.1 ± 0.0 | 3.3 ± 0.6 | 0.1 ± 0.0 |
| Intestines | 9.7 ± 0.4 | 63.8 ± 2.9 | – | – |
| Stomach | 1.3 ± 0.3 | 4.2 ± 3.9 | – | – |
| Brain | 1.6 ± 0.5 | 0.1 ± 0.0 | 1.8 ± 0.2 | 0.1 ± 0.0 |
| Blood | 5.8 ± 0.4 | 0.7 ± 0.1 | 0.8 ± 0.1 | 0.1 ± 0.0 |
Mice were anesthetized with isoflurane (2% in oxygen) and injected i.v. with ~9.25 MBq. Data are expressed as mean ± standard deviation;
a
Percentage of injected dose calculated as counts per minute in organ/total counts per minute recovered;
b
Standard uptake value calculated as (radioactivity as counts per minute in organ/weight of the organ in grams)/(total counts recovered / body weight in grams).