Table 2.
Tissue distribution of [18F]MA3 in control mice at 2, 10, 30, and 60 min post injection (n = 3 or 4 per time point).
| [18F]MA3 | % IDa | SUVb | ||||||
|---|---|---|---|---|---|---|---|---|
| 2 min | 10 min | 30 min | 60 min | 2 min | 10 min | 30 min | 60 min | |
| Bladder + urine | 0.2 ± 0.2 | 0.4 ± 0.0 | 1.7 ± 0.3 | 1.6 ± 1.4 | – | – | – | – |
| Kidneys | 9.0 ± 1.2 | 1.6 ± 0.2 | 1.0 ± 0.2 | 0.7 ± 0.3 | 5.4 ± 0.4 | 1.1 ± 0.1 | 0.6 ± 0.1 | 0.5 ± 0.1 |
| Liver | 31.4 ± 8.4 | 26.1 ± 3.4 | 17.3 ± 6.7 | 10.2 ± 5.2 | 7.2 ± 2.0 | 4.7 ± 0.7 | 3.7 ± 1.4 | 2.1 ± 1.1 |
| Spleen | 0.4 ± 0.1 | 0.3 ± 0.1 | 0.1 ± 0.0 | 0.03 ± 0.01 | 5.1 ± 0.6 | 0.5 ± 0.0 | 0.5 ± 0.3 | 0.5 ± 0.1 |
| Pancreas | 1.4 ± 0.3 | 0.4 ± 0.1 | 0.2 ± 0.1 | 0.1 ± 0.0 | 3.0 ± 0.5 | 0.8 ± 0.0 | 0.4 ± 0.1 | 0.3 ± 0.1 |
| Lungs | 1.2 ± 0.3 | 0.5 ± 0.0 | 0.2 ± 0.0 | 0.1 ± 0.0 | 2.8 ± 0.7 | 0.7 ± 0.1 | 0.4 ± 0.1 | 0.3 ± 0.1 |
| Heart | 1.2 ± 0.1 | 0.3 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | 3.4 ± 0.3 | 0.6 ± 0.0 | 0.4 ± 0.1 | 0.3 ± 0.0 |
| Intestines | 9.4 ± 3.9 | 30.8 ± 6.1 | 56.2 ± 5.4 | 64.4 ± 2.6 | – | – | – | – |
| Stomach | 1.4 ± 0.2 | 0.5 ± 0.0 | 0.8 ± 1.0 | 4.4 ± 5.1 | – | – | – | – |
| Brain | 1.2 ± 0.2 | 1.0 ± 0.1 | 0.3 ± 0.1 | 0.1 ± 0.0 | 1.1 ± 0.1 | 0.5 ± 0.0 | 0.2 ± 0.0 | 0.1 ± 0.0 |
| Blood | 5.4 ± 0.4 | 2.2 ± 0.3 | 1.2 ± 0.1 | 1.0 ± 0.3 | 0.8 ± 0.1 | 0.3 ± 0.0 | 0.2 ± 0.0 | 0.1 ± 0.0 |
| Bone | 5.3 ± 1.2 | 3.5 ± 0.2 | 1.6 ± 0.5 | 2.2 ± 0.3 | 0.4 ± 0.1 | 0.3 ± 0.0 | 0.1 ± 0.0 | 0.2 ± 0.0 |
Mice were anesthetized with isoflurane (2% in oxygen) and injected i.v. with ~0.92 MBq. Data are expressed as mean ± standard deviation;
a
Percentage of injected dose calculated as counts per minute in organ/total counts per minute recovered;
b
Standard uptake value calculated as (radioactivity as counts per minute in organ/weight of the organ in grams)/(total counts recovered/body weight in grams).