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Characterization of MA2, MA3, 12, and NE40 in functional cAMP assays and radioligand binding assays with [3H]CP55940.
| NE40 | MA2 | MA3 | 12 | |
|---|---|---|---|---|
| hCB2 cAMP EC50 [nM] (% eff) | 8 (−178) | 3 (101) | 0.13 (102) | 0.15 (100) |
| mCB2 cAMP EC50 [nM] (% eff) | 11 (−128) | 2 (100) | 0.09 (101) | 0.18 (100) |
| EC50 ratio hCB1/hCB2 | > 1250 | 430 | 563 | 1300 |
| hCB2 Ki [nM] | 4 | 87 | 0.8 | 2.8 |
| hCB1 Ki [nM] | 1037 | 1611 | 102 | 568 |
| Ki ratio hCB1/hCB2 | 241 | 19 | 127 | 202 |
| mCB2 Ki [nM] | 2 | 241 | 2.6 | 4.6 |
