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. 2016 Jun 10;31(5):1095–1104. doi: 10.1007/s11011-016-9852-8

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Effect of acute (panel A) and subchronic (panel B) treatment with sildenafil in the forced swim test in reserpine-treated mice. In acute studies, sildenafil was administered i.p. 30 min before the test. In subchronic studies, sildenafil was administered once daily for 14 consecutive days. Reserpine was injected i.p. 240 min before the test. Control animals received 1 % Tween 80 + 1 % DMSO. Each experimental group consisted of 11–12 animals. Data are presented as means + SEM. ** p < 0.01, *** p < 0.001 as compared to the control group; ^### p < 0.001 as compared to the reserpine-treated group (one-way ANOVA followed by Tukey post hoc test)