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. 2016 Jun 10;31(5):1095–1104. doi: 10.1007/s11011-016-9852-8

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Effect of acute (panel A) or subchronic (panel B) treatment with sildenafil and acute restraint stress on serum corticosterone concentrations in mice. In acute studies, sildenafil was administered i.p. 30 min before the test. In subchronic studies, sildenafil was administered once daily for 14 consecutive days. Control animals received 1 % Tween 80 + 1 % DMSO. Each experimental group consisted of 9–11 animals. *** p < 0.001 as compared to the non-stressed control group; ^### p < 0.001 as compared to the control stressed group (two-way ANOVA followed by Bonferroni post hoc test)