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. 2016 Sep 22;7:379. doi: 10.3389/fimmu.2016.00379

Figure 5.

Figure 5

Administering indomethacin to mice with 4-NQO-induced premalignant lesions increases spleen cell cytokine production at 6 and 20 weeks post-onset of treatment. Spleens from mice receiving indomethacin or diluent control treatments were collected at 6 and 20 weeks after onset of diluent control or indomethacin treatment. Spleen cells were cultured for 72 h at 1 × 106 cells/well and supernatants were collected for quantitation of secreted IL-2 (A), IFN-γ (B), IL-17A (C), and TNF-α (D). Five mice were examined for each group per time point. Spleen cells from untreated healthy control C57BL/6 mice served as controls. Data are shown as fold change from values for spleen cells from healthy control mice. Data represent mean ± SEM (two-tailed Student’s t-test).