Skip to main content
. 2016 Sep 8;2016:8263463. doi: 10.1155/2016/8263463

Figure 4.

Figure 4

Effect of acute and repetitive treatments of the DS10/HS100 mg/kg dose on mechanical and thermal hyperalgesia after inducing CCI in rats. Time course curves show the effect of an acute dose of diosmin 10 mg/kg and hesperidin 100 mg/kg in comparison with both their combination DS10/HS100 mg/kg and vehicle on the withdrawal threshold after mechanical stimulus (a) and on the withdrawal latency after thermal stimulus, assessed every 30 minutes over a 2 h period (b). Panels (c) and (d) show the effect of daily repetitive administration of a combination of DS10/HS100 mg/kg, gabapentin (GBP), and vehicle on both withdrawal threshold after mechanical stimulus (c) and withdrawal latency after thermal stimulus (d), assessed on days 15, 18, 21, 24, and 28 after surgery. Each point is the average of the withdrawal threshold (g) or withdrawal latency (s) ± SEM in at least six rats. Two-way ANOVA followed by Tukey's test, asterisks indicate statistical significance among the vehicle and the treatment groups on the same day: ∗ P < 0.05, ∗∗ P < 0.01, and ∗∗∗ P < 0.001.