Figure 5.

Antihyperalgesic effect obtained from the time course curves of the following compounds alone and in presence of the combination DS10/HS100 mg/kg in the CCI model: naloxone (1 mg/kg, i.p.), bicuculline (5 mg/kg, i.p.), haloperidol (0.1 mg/kg, i.p.), and WAY100635 (0.1 mg/kg, s.c.) on the withdrawal threshold at 30 min (a) and 120 min (b) and withdrawal latency at 30 min (c) and 120 min (d). Each column is the average of withdrawal threshold (g) or withdrawal latency (s) ± SEM in at least six rats. Three-way ANOVA followed by Tukey's test, symbols indicate statistical significance among the DS/HS alone group and the antagonist with DS/HS groups: ^∗ P < 0.05, ^∗∗ P < 0.01, and ^¥ P < 0.001 versus vehicle; ⁺ P < 0.001 versus naloxone, ^● P < 0.001 versus bicuculline, and ^¤ P < 0.001 versus WAY100635.