Table 2.
Urinary levels of tubular biomarkers with different stages of albuminuria in the rapid and nonrapid GFR decline groups.
| Urine biomarkers | N | GFR decline < 25% per year | N | GFR decline ≥ 25% per year | P value |
|---|---|---|---|---|---|
| Median (IQR) | Median (IQR) | ||||
| UCCR (mcg/gm) | |||||
| (i) All patients (N = 303) | 262 | 3.01 (1.04, 6.46) | 41 | 7.52 (4.74, 10.27) | <0.001∗ |
| (ii) Normoalbuminuria (N = 94) | 90 | 1.50 (0.21, 3.25) | 4 | 3.93 (1.87, 7.67) | 0.116 |
| (iii) Microalbuminuria (N = 95) | 91 | 2.43 (0.95, 3.73) | 4 | 2.36 (0.77, 4.36) | 0.950 |
| (iv) Macroalbuminuria (N = 114) | 81 | 7.60 (4.23, 12.71) | 33 | 8.11 (6.07, 11.61) | 0.696 |
| UANG (mcg/gm) | |||||
| (i) All patients (N = 303) | 262 | 2.41 (0.31, 10.73) | 41 | 14.26 (3.29, 24.48) | <0.001∗ |
| (ii) Normoalbuminuria (N = 94) | 90 | 0.49 (0.11, 1.71) | 4 | 1.77 (0.67, 5.35) | 0.277 |
| (iii) Microalbuminuria (N = 95) | 91 | 1.83 (0.35, 5.82) | 4 | 3.13 (0.79, 5.48) | 0.879 |
| (iv) Macroalbuminuria (N = 114) | 81 | 13.96 (5.32, 23.21) | 33 | 14.74 (9.26, 27.88) | 0.585 |
| UKIM-1 (ng/gm) | |||||
| (i) All patients (N = 303) | 262 | 67.5 (32.1, 132.2) | 41 | 133.1 (81.9, 255.6) | <0.001∗ |
| (ii) Normoalbuminuria (N = 94) | 90 | 37.4 (16.4, 65.9) | 4 | 55.9 (53.2, 116.7) | 0.073 |
| (iii) Microalbuminuria (N = 95) | 91 | 67.0 (32.1, 121.8) | 4 | 53.8 (28.1, 79.2) | 0.457 |
| (iv) Macroalbuminuria (N = 114) | 81 | 129.2 (88.3, 209.5) | 33 | 178.9 (104.9, 371.8) | 0.077 |
| UNGAL (ng/gm) | |||||
| (i) All patients (N = 303) | 262 | 751.3 (413.9, 1350.5) | 41 | 1058.3 (702.1, 1693.3) | 0.004∗ |
| (ii) Normoalbuminuria (N = 94) | 90 | 495.15 (342.1, 801.8) | 4 | 662.1 (391.7, 1064.85) | 0.594 |
| (iii) Microalbuminuria (N = 95) | 91 | 654.7 (390.6, 1245.7) | 4 | 625.3 (323.55, 1144.2) | 0.701 |
| (iv) Macroalbuminuria (N = 114) | 81 | 1199.6 (787.3, 1942) | 33 | 1347.6 (886.6, 1812.6) | 0.795 |
∗ P < 0.05 versus group with GFR decline < 25% per year.
Note: values for continuous variables are represented as median [interquartile range].
UANG: urine angiotensinogen creatinine ratio; UCCR: urine cystatin-C creatinine ratio; UKIM-1: Urine Kidney Injury Molecule-1 creatinine ratio; UNGAL: Urine Neutrophil Gelatinase Associated Lipocalin creatinine ratio.