Figure 5.
Q7 impairs ACh-induced vasodilation in an NO-dependent mechanism. Original trace showing the time course of the concentration–response curves to PE (10−9–10−6 M) and ACh (10−8–10−5 M) in intact aortic rings of rats: control (a) and in the presence of 10−5 M Q7 for 30 min (b). After an equilibration period and before PE, the aortic rings were stabilized by two successive near-maximal contractions with 6 × 10−2 M KCl. ACh-response curves in endothelium-intact rat aorta in the presence or absence (control) of Q7 (10−6 M, 10−5 M) (c). Arteries were preconstricted with 10−6 M PE. SNP-response curves in rat aorta in the presence or absence (control) of 10−5 M Q7 (d). Data are the average ± SEM of 4-5 independent experiments. ∗ p < 0.05 versus control.