Figure 7.

Q7 increases PE-dependent vasoconstriction in a Ca²⁺-dependent manner. PE-response curves in endothelium-intact rat aorta in the presence or absence (control) of 10⁻⁵ M Q7 (a). The vascular tissue was preincubated in a KRB buffer without calcium for 10 min before 10⁻⁶ M PE was added; and then, the CaCl₂ (0.1, 0.3, 0.6, and 1.0 × 10⁻³ M) was added to the bath (b). Data are the average ± SEM of 4-5 independent experiments. ^∗ p < 0.05 and ^∗∗ p < 0.01 versus control.