Figure 8.
Acute effect of Q7 on potassium channels in rat aorta. Q7 significantly decreases the vascular contractile response involved potassium channels. The contraction with 10−3 M BaCl2 (a) and effect of 10−2 M KCl (b) in rat aorta precontracted with 10−3 M BaCl2 are shown. Open bar (control, vehicle), black bar (10−5 M Q7), and striped bar (10−5 M Q7 + 10−8 M SNP). Percentages of contraction with BaCl2 were determined with respect to submaximal contraction with 6 × 10−2 M KCl (a), and the percentages of contraction in presence of 10−2 M KCl were determined with respect to maximal contraction with 10−3 M BaCl2 (b). Data are the average ± SEM of 4-5 independent experiments. ∗ p < 0.05 and ∗∗∗ p < 0.001 versus control.