Table 3.
Muscle morphology: parameters obtained from biopsy of m. vastus lateralis ∗.
| Variable | Patients n = 10 |
Controls n = 10 |
p (95% CI lower; upper)∧ |
|---|---|---|---|
| Muscle fiber distribution | |||
| Type I, % | 54.9 ± 13.8 (33.6–76.8) | 48.5 ± 11.4 (30.5–68.3) | 0.32 (−7.5; 20.5) |
| Type II, % | 45.1 ± 13.8 (23.2–66.4) | 51.5 ± 11.4 (31.7–69.5) | 0.34 (−4.2; 10.8) |
|
| |||
| Ratio CSA type II/type I | 1.05 ± 0.17 (0.83–1.37) | 1.27 ± 0.22 (0.95–1.94) | 0.05 (−0.442; −0.002) |
|
| |||
| Myonuclei | |||
| Type I, pr. fiber | 3.6 ± 1.1 (2.2–6.0) | 3.8 ± 0.6 (3.1–4.8) | 0.65 (−0.96; 0.63) |
| Type II, pr. fiber | 4.0 ± 1.1 (2.6–6.0) | 4.6 ± 1.0 (3.2–6.5) | 0.25 (−1.75; 0.51) |
|
| |||
| Central nuclei | |||
| Type I, pr. fiber | 0.02 ± 0.03 (0.00–0.10) | 0.08 ± 0.14 (0.00–0.44) | 0.20§ |
| Type II, pr. fiber | 0.03 ± 0.03 (0.00–0.08) | 0.08 ± 0.11 (0.00–0.32) | 0.26§ |
|
| |||
| Satellite cells, Pax7-positive | |||
| Type I, pr. 100 fibers | 8.8 ± 8.0 (1.5–29.7) | 6.4 ± 4.2 (1.6–17.1) | 0.62 (−0.61; 0.97)£ |
| Type II, pr. 100 fibers | 5.5 ± 2.7 (2.6–11.3) | 8.0 ± 6.0 (3.4–24.3) | 0.13 (−0.76; 0.12)£ |
∗Values are mean ± SD (range) unless otherwise indicated. §Wilcoxon signed ranks test. £Log-transformed variable, paired samples t-test. CD68: marker for macrophages. CD66b: marker for neutrophils. CSA: cross-sectional area. ECM: extracellular matrix. ∧Comparison between groups tested by paired samples t-test unless otherwise indicated.