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(A) Western blot analysis showed that both ATF3 and p-c-jun levels were similarly induced in a time- and dose-dependent manner in both the Calu6 and H23 parental lines. (B and C) The MCF7 and T47D breast carcinoma cell lines and the LNCAP and PC3 prostate carcinoma cell lines also demonstrated a dose-dependent ATF3 and p-c-jun induction following cisplatin treatments (0-8 μg/ml, 24 hours).
