Figure 4.

Ets-2 deletion does not affect fibroblast proliferation or collagen deposition.

(A–C) GSEA enrichment plots for Ets2-regulated genes, ECM remodeling, and inflammation pathways in KE and KCE fibroblasts (n = 3). (D and E) Dual-color IHC of SMA (red) and Ki67 (brown) and quantification showing the percentage of proliferating SMA+ cells, indicated by black arrows. (F and G) Masson's Trichrome stain and quantification of the percent area of collagen staining (n = 7; red bar indicates mean).