Figure 6.

Ets-2 directly regulates chemokine and cytokine production.

(A) GSEA enrichment plots for cytokine and chemokine pathways in KE versus KCE fibroblasts (n = 3). (B) qRT-PCR of secreted factors in KE and KCE mouse fibroblasts (normalized to Rpl4, represented as fold-change relative to ETS2^WT expression; n = 3; bars represent means ± SD; N.E. = not expressed). (C) qRT-PCR of secreted factors in human PDAC-derived CAF cultures (normalized to Rpl4, represented as fold-change relative to normal fibroblast expression; n = 3; bars represent means ± SD). (D) Relative enrichment for ETS2 binding to the promoters of indicated genes in KE and KCE mouse fibroblasts (n = 5; bars represent means ± SD).