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. 2016 Sep 8;2016:5860657. doi: 10.1155/2016/5860657

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Copyright © 2016 Daria Sollazzo et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Analysis of the circulating levels of CRT, IL-6, and TNF-α proteins. The CRT plasma levels of total MF (a) or MF subdivided into JAK2 ^V617F-mutated (n = 16), CALR-mutated (n = 10), MPL-mutated (n = 3), and triple-negative-mutated (n = 1) groups (b) were measured by ELISA. Compared with age-matched controls (HD; n = 10), CRT plasma levels were significantly increased in MF patients (p = 0.0028). Of note, there was no significant difference between the mutated groups. Irrespective of mutational status, TNF-α (c) and IL-6 (d) blood plasma levels were also increased in MF (p = 0.008). For all graphs, one symbol represents one individual, and the height of the bar represents the median value. ^∗∗ p ≤ 0.01; ^∗∗∗ p ≤ 0.001.