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. 2016 Sep 20;18(9):567–576. doi: 10.1016/j.neo.2016.07.008

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© 2016 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Indication of activated pathways in HIF2A PGLs. (A) IPA revealed increased expression of a vast number of genes essential in oxidative phosphorylation in HIF2A PGLs (red indicates upregulation in HIF2A PGLs compared with pseudohypoxic PGLs). (B) Heatmap depicting upregulation of oxidative phosphorylation genes in HIF2A PGLs after comparison of differentially expressed genes in HIF2A compared with other pseudohypoxic PGLs with the oxydative phosphorylation genes listed in the Kyoto Encyclopedia of Genes and Genomes (red indicates upregulation). (C) Upregulation of several genes for ribosomal proteins led to prediction of increased protein synthesis and MYCN activation in HIF2A PGLs by IPA.