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Pathways involved in PCSK9-mediated inflammation. Intracellular PCSK9, including the internalized one which escapes lysosomal degradation could eventually undergoes re-secretion but exerts cytoplasmic effects that might regulate the expression of genes controlling inflammation (1). PCSK9 could also target LRP-1 which is involved in the activation of JAK/STAT and ERK pathways (2).
