Table 1. Characteristics of studies included in genetically engineered mouse models.
| Source | Group | Tumor characteristics |
IGF-1, ng/ml | Leptin, ng/ml | Adiponectin, μg/ml | |||
|---|---|---|---|---|---|---|---|---|
| No. with tumor/subjects | Age at detection, week | No. of tumors/animal | Weight, g | |||||
| Berrigan28 | ICR | 24/31 | NA | NA | NA | 473 ± 54.1 | 14.7 ± 3.7 | NA |
| CCR | 27/31 | NA | NA | NA | 412 ± 24.1 | 4.8 ± 1.7 | NA | |
| Cleary23 | ICR | 1/30 | 80 | 1.0 | 0.06 | 553.6 ± 37.5 | NA | NA |
| CCR | 15/33 | 73.5 ± 2.2 | 1.7 ± 0.3 | 0.67 ± 0.13 | 467.7 ± 22.5 | NA | NA | |
| Pape-Ansorge34 | ICR | 7/31 | 56.9 ± 6.7 | 1.3 ± 0.2 | 1.29 ± 0.27 | 626 ± 16 | NA | NA |
| CCR | 11/33 | 54.0 ± 4.1 | 1.7 ± 0.2 | 1.69 ± 0.16 | 567 ± 21 | NA | NA | |
| Cleary22 | ICR | 6/39 | 79.4 ± 0.3 | 1.6 ± 0.4 | 0.48 ± 0.25 | R:369 ± 28 RF:457 ± 22 | NA | NA |
| CCR | 11/30 | 74.5 ± 2.6 | 1.8 ± 0.4 | 0.24 ± 0.09 | 383 ± 20 | NA | NA | |
| Bonorden29 | ICR | 92/101 | 38 | NA | NA | R:296.9 ± 18.4* RF:322.7 ± 14.8* | R:1.2 ± 0.2* RF:2.8 ± 0.3* | R:18.3 ± 1.9* RF:16.2 ± 1.7* |
| CCR | 75/79 | 35 | NA | NA | 388.8 ± 12.2* | 2.6 ± 0.3* | 11.4 ± 0.8* | |
| Rogozina26 | ICR | 6/66 | 67.0 ± 4.2 | 1.0 | 0.66 ± 0.38 | R:476.8 ± 38.9* RF:656.8 ± 29.2* | NA | NA |
| CCR | 23/65 | 69.0 ± 1.6 | 1.39 ± 0.2 | 0.43 ± 0.04 | 630.9 ± 27.8* | NA | NA | |
| Dogan31 | ICR | 6/52 | 55 | NA | NA | R:195 ± 6 RF:211 ± 21 | R:2.6 ± 0.4 RF:2.9 ± 0.7 | R:25.1 ± 3.5 RF:17.5 ± 2.2 |
| CCR | 8/40 | 37 | NA | NA | 298 ± 21 | 5.4 ± 1.1 | 14.7 ± 1.2 | |
| Lanza-Jacoby32 | ICR | 4/15 | NA | NA | NA | 284.1 ± 17.9 | 1.2 ± 0.2 | 9.9 ± 0.6 |
| CCR | 6/15 | NA | NA | NA | 226.4 ± 12.2 | 0.9 ± 0.2 | 9.7 ± 0.6 | |
| Mizuno33 | ICR | 17/29 | 49.1 | NA | 1.4 | 386.5 ± 73.6* | 0.8 ± 0.3* | 7.4 ± 0.2* |
| CCR | 17/36 | 52.4 | NA | 1.5 | 656.4 ± 49.1* | 3 ± 0.6* | 6.2 ± 0.5* | |
| Rogozina27 | ICR | 2/45 | 82.0 ± 0.0 | 1.0 ± 0.001 | 0.05 ± 0.0 | R:231.4 ± 66.0* RF:382.6 ± 22.7* | R:3.2 ± 2.1* RF:13.2 ± 8.7* | R:11.5 ± 4.4* RF:8.1 ± 4.3* |
| CCR | 23/44 | 74.5 ± 1.6 | 1.7 ± 0.16 | 0.75 ± 0.24 | 305.2 ± 19.6* | 11.0 ± 10.1* | 11.2 ± 5.9* | |
| Grossmann30 | ICR | 12/30 | NA | NA | NA | NA | NA | NA |
| CCR | 17/33 | NA | NA | NA | NA | NA | NA | |
Values are means ± SE.
CCR: chronic calorie restriction; ICR: intermittent calorie restriction; IGF-1: insulin-like growth factor 1; NA: not available; R: results of ICR restriction periods; RF: results of ICR refeeding periods; SE: standard error.
*Data were extracted from the original figures using GetData Graph Digitizer.