Table 4. Performance of imaging change and microvessel change in predicting pCR and MHR (pCR = pathological complete response.
| Folder change | P value | AUC | Cutoff | Sensitivity | Specificity | PPV | NPV | |
|---|---|---|---|---|---|---|---|---|
| pCR vs. non-pCR (n = 8 vs. n = 40) | ||||||||
| 3D-CEUS score | 0.1 | 0.0001 | 0.934 (0.824–0.968) | <1 | 88% | 100% | 100% | 98% |
| DCE-MRI score | 0.1 | <0.0001 | 0.970 (0.875–0.998) | <1 | 88% | 98% | 88% | 98% |
| Δ3D-CEUS | 2.4 | <0.0001 | 0.991 (0.909–1.000) | >6 | 88% | 100% | 100% | 98% |
| ΔDCE-MRI | 2.3 | <0.0001 | 0.987 (0.903–1.000) | >5 | 100% | 95% | 80% | 100% |
| MHR vs. NMHR (n = 20 vs. n = 28) | ||||||||
| 3D-CEUS score | 0.5 | 0.0003 | 0.810 (0.671–0.909) | <1 | 35% | 100% | 100% | 68% |
| DCE-MRI score | 0.3 | <0.0001 | 0.906 (0.787–0.971) | <1 | 40% | 100% | 100% | 70% |
| Δ3D-CEUS | 2.5 | <0.0001 | 0.993 (0.913–1.000) | >4 | 90% | 100% | 100% | 94% |
| ΔDCE-MRI | 2.4 | <0.0001 | 0.982 (0.894–1.000) | >4 | 100% | 93% | 91% | 100% |
| MHR vs. NMHR (n = 12 vs. n = 28) | ||||||||
| Δ MVD (unit, 103) | 1.3 | 0.2497 | 0.616 (0.449–0.765) | >4.32 | 58% | 71% | 47% | 80% |
| Δ VEGF | 1.3 | 0.0766 | 0.679 (0.512–0.817) | >3 | 18% | 100% | 100% | 74% |
MHR major histological response. NMHR = non-major histological response. AUC=area under the curve. PPV = positive predictive value. NPV = negative predictive value. DCE-MRI = dynamic contrast enhanced magnetic resonance imaging. 3D-CEUS = three dimensional contrast enhanced ultrasound. Δ3D-CEUS = score difference before and after treatment. ΔDCE-MRI = score difference before and after treatment. MVD = microvessel density. VGEF = vascular endothelial growth factor. ΔMVD = difference of MVD before and after treatment. ΔVEGF = difference of VEGF before and after treatment).