Table 1. DNA methylation-based age predictive models.
| Models | Age signaturesa | Gene | Tissue | Analysis platform | Accuracyb |
|---|---|---|---|---|---|
| Bocklandt et al. (10) | cg09809672 | EDARADD | Saliva | 27K array | 5.2 years |
| cg27210390 | TOM1L1 | ||||
| cg12799895 | NPTX2 | ||||
| Koch & Wagner (49) | cg12799895 | NPTX2 | Various tissues | 27K array | 11 years |
| cg07533148 | TRIM58 | ||||
| cg25148589 | GRIA2 | ||||
| cg01530101 | KCNQ1DN | ||||
| cg23571875 | BIRC4BP | ||||
| Hannum et al. (11) | 71 CpG sites | Blood | 450K array | 3.9 yearsc | |
| Horvath (12) | 353 CpG sites | Various tissues | 27K & 450K array | 3.6 yearsc | |
| Weidner et al. (13) | cg25809905 | ITGA2B | Blood | Pyrosequencing | 4.3 years |
| cg02228185 | ASPA | ||||
| cg17861230 (−14 bp) | PDE4C | ||||
| Zbieć-Piekarska et al. (55) | cg16867657 (−2 bp) | ELOVL2 | Blood | Pyrosequencing | 5.0 years |
| cg16867657 (−10 bp) | |||||
| Zbieć-Piekarska et al. (56) | cg16867657 (−10 bp) | ELOVL2 | Blood | Pyrosequencing | 3.9 years |
| cg10501210 (＋6 bp) | C1orf132 | ||||
| cg07553761 (＋10 bp) | TRIM59 | ||||
| cg14361627 | KLF14 | ||||
| cg06639320 (＋6 bp) | FHL2 | ||||
| Park et al. (57) | cg21572772 | ELOVL2 | Blood | Pyrosequencing | 3.4 years |
| cg04208403 | ZNF423 | ||||
| cg19283806 | CCDC102B | ||||
| Lee et al. (58) | cg06304190 | TTC7B | Semen | Methylation SNaPshot | 5.4 years |
| cg06979108 | NOX4 | ||||
| cg12837463 | |||||
| Bekaert et al. (60) | cg02228185 | ASPA | Blood, teeth | Pyrosequencing | 4.9 years |
| cg17861230 (−14 bp) | PDE4C | ||||
| cg16867657 (−4 bp) | ELOVL2 | ||||
| cg09809672 | EDARADD | ||||
| Giuliani et al. (61) | 4 CpG units | ELOVL2 | Cementum, dental pulp | EpiTYPER | 1.2 yearsd |
| 4 CpG units | FHL2 | ||||
| 5 CpG units | ELOVL2 | Dental pulp | 2.3 yearsd | ||
| 5 CpG units | FHL2 | ||||
| 3 CpG units | PENK | ||||
| 7 CpG units | ELOVL2 | Cementum | 2.5 yearsd | ||
| 4 CpG units | FHL2 | ||||
| 1 CpG units | PENK | ||||
| 3 CpG units | ELOVL2 | Dentin | 7.1 yearsd | ||
| 1 CpG units | FHL2 | ||||
| 1 CpG units | PENK | ||||
aAge signatures indicate the CpGs used for model construction. When CpG differs from that investigated in the BeadChip array, distance is indicated in parenthesis. + and − indicates downstream and upstream, respectively. bAccuracy is indicated by MAD from chronological age. When indicated by root-mean-square error or median of absolute difference, accuracy is marked by superscript c or d, respectively.