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. 2016 Sep 22;6:33949. doi: 10.1038/srep33949

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Molecular interactions of gefitinib with selected human off-targets; (A) mutant EGFR kinase domain; (B) PIM- 1, (C) MAPK10; (D) CHEK1; (E) DHODH; (F) ERBB4; (G) CHK2 and (H) HSD17B1. PDB codes are shown in brackets. The H-bond and polar interactions are represented by black line and green lines respectively.