| 1 |
BMPR1B |
3MDY |
O00238 |
PF08515 |
Human |
positive regulation of chondrocyte differentiation |
cell membrane |
| 2 |
SRC SRC1 |
1YOL, 1Y57 3EN5, 3EN7, 3EN4 |
P12931 P00523
|
PF07714 |
Human Chicken |
regulation of cytoskeletal organization, activation of EGF-mediated calcium- chloride channel |
cell membrane, mitochondrial inner membrane, nucleus, cytoplasm |
| 3 |
FGFR2 BEK KGFR KSAM |
3RI1, 1OEC |
P21802 |
PF07714 |
Human |
regulates the cell proliferation, differentiation, migration, apoptosis, and embryonic development |
cell membrane, Golgi apparatus, cytoplasmic vesicles |
| 4 |
ACVRL1 ACVRLK1 ALK1 |
3MY0 |
P37023 |
PF08515 |
Human |
regulator of normal blood vessel development |
cell membrane |
| 5 |
MAPK8 JNK1 PRKM8 SAPK1 SAPK1C |
3ELJ |
P45983 |
PF00069 |
Human |
regulates the circadian clock |
cytoplasm, nucleus |
| 6 |
ALK |
2XBA |
Q9UM73 |
ALK_HUMAN |
Human |
genesis and differentiation of the nervous system |
cell membrane |
| 7 |
Comp |
1FBM |
P35444 |
COMP_RAT |
Rat |
regulates structural integrity of cartilage |
extra cellular matrix |
| 8 |
AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6 |
3LAU, 3UOH |
O14965 |
PF00069 |
Human |
regulates cell cycle progression |
cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
| 9 |
DMPK DM1PK MDPK |
2VD5 |
Q09013 |
DMPK_HUMAN |
Human |
maintains skeletal muscle structure and function |
cell membrane, ER membrane, mitochondrial outer membrane |
| 10 |
SLK KIAA0204 STK2 |
2J51 |
Q9H2G2 |
PF00069 |
Human |
mediates apoptosis and actin stress fiber dissolution |
cytoplasm |
| 11 |
ERBB4 HER4 |
2R4B |
Q15303 |
PF07714 |
Human |
regulates development of the heart, the central nervous system and the mammary gland, promote apoptosis |
cell membrane, nucleus and mitochondria |
| 12 |
ttgR T1E_0244 |
2UXH |
Q9AIU0 |
TTGR_PSEPT |
Pseudomonas putida (strain DOT-T1E) |
responsible for antibiotics resistance |
not known |
| 13 |
TNK2 ACK1 |
3EQR |
Q07912 |
ACK1_HUMAN |
Human |
involved in trafficking and clathrin-mediated endocytosis |
cell membrane, nucleus, endosome |
| 14 |
EGFR ERBB ERBB1 HER1 |
3UG2, 3LZB |
P00533 |
EGFR_HUMAN |
Human |
activates several signal cascades |
cell membrane, ER membrane nucleus membrane, Golgi membrane, endosome |
| 15 |
STK25 SOK1 YSK1 |
2XIK |
O00506 |
STK25_HUMAN |
Human |
response against environmental stress |
cytoplasm, Golgi apparatus |
| 16 |
LCK |
3KMM, 3KXZ, 3ACK, 3MPM, 3AC3, 3AC2, 3AD4 |
P06239 |
LCK_HUMAN |
Human |
responsible for selection and maturation of developing T-cells |
cytoplasm, cell membrane |
| 17 |
IGF1R |
2ZM3 |
P08069 |
IGF1R_HUMAN |
Human |
involved in cell growth and survival control |
cell membrane |
| 18 |
CHEK1 CHK1 |
2HOG, 2E9N, 4FTI, 4FSR, 2XF0, 2HXL, 4FTQ, 2HY0, 4FT3, 4FTN, 2BRB, 2BRH, 2XEY, 4FTO, 2QHM, 2E9U, 4FT0, 3UN9, 4FTC, 2BR1 |
O14757 |
CHK1_HUMAN |
Human |
required for cell cycle arrest and activation of DNA repair |
nucleus, cytoplasm |
| 19 |
PRKCI DXS1179E |
1ZRZ |
P41743 |
KPCI_HUMAN |
Human |
Plays a protective role against apoptotic stimuli |
cytoplasm, membrane, nucleus, endosome |
| 20 |
MAP3K9 MLK1 PRKE1 |
3DTC |
P80192 |
M3K9_HUMAN |
Human |
role in the cascades of cellular responses |
intracellular |
| 21 |
FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR |
3TT0, 4F64 |
P11362 |
FGFR1_HUMAN |
Human |
essential for regulation of embryonic development, cell proliferation, differentiation and migration |
cytoplasm, cell membrane, nucleus, cytoplasmic vesicles |
| 22 |
MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A |
1DI9, 3FLW, 3KF7, 3ROC, 3IW7, 3FLZ, 3MVM, 2ZB1, 2RG6, 1WBW |
Q16539 |
MK14_HUMAN |
Human |
essential component of the MAP kinase signal transduction pathways responsible for activating the cascades of cellular responses |
cytoplasm. nucleus |
| 23 |
KIT SCFR |
3G0E |
P10721 |
KIT_HUMAN |
Human |
responsible for regulation of hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, and in melanogenesis |
cytoplasm, cell membrane |
| 24 |
STK17B DRAK2 |
3LM0 |
O94768 |
ST17B_HUMAN |
Human |
positive regulator of apoptosis |
cell membrane, nucleus |
| 25 |
aurkb-a airk2-a |
2VRX |
Q6DE08 |
AUKBA_XENLA |
Xenopus laevis |
key regulator of mitosis |
nucleus, chromosomes |
| 26 |
ACK2 |
1ZOH |
P28523 |
CSK2A_MAIZE |
Zea mays (Maize) |
utilizes acidic proteins |
not known |
| 27 |
ABL1 ABL JTK7 |
3UE4, 3KF4 (Mouse) |
P00519 |
ABL1_HUMAN |
Human |
responsible for cell growth and survival |
cytoplasm, nucleus, mitochondria |
| 28 |
MAPK10 JNK3 JNK3A PRKM10 SAPK1B |
2O2U, 4Z9L, 3CGO, 2O0U, 3TTJ, 2ZDT |
P53779 |
MK10_HUMAN |
Human |
involved in neuronal proliferation, differentiation, migration and programmed cell death |
cytoplasm. nucleus, mitochondria, membrane |
| 29 |
MAPKAPK2 |
3KA0 |
P49137 |
MAPK2_HUMAN |
Human |
involved in cytokine production, endocytosis, reorganization of the cytoskeleton, chromatin remodeling and DNA damage response |
cytoplasm, nucleus |
| 30 |
BTK AGMX1 ATK BPK |
3PJ1, 3PJ2, 3OCT |
Q06187 |
BTK_HUMAN |
Human |
Vital for B lymphocyte development, differentiation and signaling |
cytoplasm. nucleus, cell membrane |
| 31 |
ACVR1 ACVRLK2 |
3MTF, 3OOM |
Q04771 |
ACVR1_HUMAN |
Human |
involved for left-right pattern formation during embryogenesis |
membrane |
| 32 |
SYK |
1XBC |
P43405 |
KSYK_HUMAN |
Human |
regulates innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development |
cytoplasm, cell membrane |
| 33 |
EPHB4 HTK MYK1 TYRO11 |
2VX1, 2VWU, 2×9F, 2VWX, 2VWW |
P54760 |
EPHB4_HUMAN |
Human |
important in tumor angiogenesis |
cell membrane |
| 34 |
CDPK1 |
3T3U, 3NYV, 3MWU, 3MA6 |
Q9BJF5A3FQ16 |
Q9BJF5_TOXGO A3FQ16_CRYPI |
Toxoplasma gondii Cryptosporidium parvum (strain Iowa II) |
binds with metals and nucleotides |
not known |
| 35 |
CDK6 CDKN6 |
3NUX |
Q00534 |
CDK6_HUMAN |
Human |
controls cell cycle and differentiation |
cytoplasm. nucleus |
| 36 |
DHODH |
3F1Q |
Q02127 |
PYRD_HUMAN |
Human |
catalyzes the conversion of dihydroorotate to orotate |
mitochondrial inner membrane |
| 37 |
CDK2 CDKN2 |
3EZV, 2UZD, 2IW6, 3R6X, 1DI8, 2VTQ, 2VU3, 2W17, 3R1Q, 1GIJ |
P24941 |
CDK2_HUMAN |
Human |
control of the cell cycle; essential for meiosis, but non-essential for mitosis |
cytoplasm. nucleus, endosome |
| 38 |
PIM1 |
3MA3, 2O65, 3R04, 3T9I, 3VBY, 3UMX, 4ENY, 3CY3, 3JY0 |
P11309 |
PIM1_HUMAN |
Human |
involved in cell survival and cell proliferation, provide advantage in tumorigenesis |
cytoplasm. nucleus, cell membrane |
| 39 |
STK10 LOK |
4BC6 |
O94804 |
STK10_HUMAN |
Human |
regulates lymphocyte migration |
cell membrane |
| 40 |
Mapk1 Erk2 Mapk Prkm1 |
2Z7L |
P63086 |
MK01_RAT |
Rat |
plays important role in the MAPK/ERK cascade |
cytoplasm, nucleus |
| 41 |
PRKACA PKACA |
3AMB, 1SZM |
P17612 P00517
|
KAPCA_HUMAN KAPCA_BOVIN |
Human Bovine |
involved in the regulation of platelets |
cytoplasm. nucleus, cell membrane, mitochondria |
| 42 |
ITK EMT LYK |
3T9T, 3V8T |
Q08881 |
ITK_HUMAN |
Human |
involved in regulation of the adaptive immune response |
cytoplasm |
| 43 |
MET |
3ZZE |
P08581 |
MET_HUMAN |
Human |
mediates entry of the pathogen into cells |
membrane |
| 44 |
CHK2 |
2YCQ, 2YIT |
O96017 |
CHK2_HUMAN |
Human |
required for checkpoint-mediated cell cycle arrest |
nucleus |
| 45 |
TTK |
3HMO |
P33981 |
TTK_HUMAN |
Human |
associated with cell proliferation |
membrane, spindle |
| 46 |
NTRK1 |
4AOJ |
P04629 |
NTRK1_HUMAN |
Human |
involved in the development and the maturation of the central and peripheral nervous systems |
cell membrane, early endosome membrane, late endosome membrane |
| 47 |
TTR |
1KGJ |
P02767 |
TTHY_RAT |
Rat |
transports thyroxine from the bloodstream to the brain |
secreted |
| 48 |
HSD17B1 |
3DHE |
P14061 |
DHB1_HUMAN |
Human |
has 20-alpha-HSD activity |
cytoplasm |
| 49 |
METF |
3FSU |
P0AEZ1 |
METF_ECOLI |
E.coli |
converts homocysteine to methionine |
cytosol |
| 50 |
BETVIA |
4A84 |
P15494 |
BEV1A_BETPN |
Betula pendula |
steroid carrier protein |
cytoplasm |
