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. 2016 Sep 22;6:33947. doi: 10.1038/srep33947

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Schematic diagram of the OIR model. Neonatal mice were exposed to 75% oxygen from postnatal day (P) 7 to P12 and returned to room air from P12 to P17 to induce maximum pathologic neovascularization at P17. Total RNAs were isolated from OIR-exposed or age-matched normoxic control mouse retinas at P17 (n = 3 per group) and subsequently applied to Affymetrix GeneChip miRNA array chips for analyzing small non-coding RNAs (sncRNAs), including mature miRNAs, pre-miRNAs (stem-loops), and snoRNAs. There were 1,412 mouse (Mus musculus) miRNAs on the array chip. (b) A dot plot illustrates the mean fold changes of miRNA expression in OIR compared with normoxic retinas versus their P-value. Each dot represents one miRNA (including pre-miRNA). Among all analyzed miRNAs, 0.92% of them (13 miRNAs, as red dots) were up-regulated at more than 1.25-fold, and 0.71% (10 miRNAs, as green dots) were down-regulated in OIR retinas at less than 0.75-fold.