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. 2016 Sep 22;6:33947. doi: 10.1038/srep33947

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) A heat map shows snoRNAs (C/D box, H/ACA box and unclassified snoRNAs) labeled as C/D box, H/ACA box and snoRNA respectively, with significantly changed levels (P < 0.05) in OIR retinas compared with age-matched normoxic controls from miRNA array data. Red color indicates up-regulated expression levels in OIR; green color indicates down-regulated expression levels. (b,c) Significant fold-changes of snoRNAs in OIR retinas versus normoxic controls expressed in log₂ scale. Thirteen snoRNAs (9 C/D box snoRNAs, 1 H/ACA box snoRNA, and 4 unclassified snoRNAs) were substantially up-regulated (b), and five snoRNAs (1 C/D box snoRNA, 1 H/ACA box snoRNA, and 3 unclassified snoRNAs) were substantially down-regulated in OIR retinas (c). Data were presented as mean ± SEM.