Table 3. OIR-responsive miRNAs and Disease-Associated Altered Expression of Genes Encoding Pertinent Experimentally Verified Targets.

miRNA ID		Verified Human Targets*	miRNA Target Genes with Altered Expression in Diseased Human Retinal Tissue24,25
						PDR	NV AMD vs. No AMD
Mouse	Human		PDR vs. No PDR	Active vs. Inactive FVM	RPE/Choroid	Neural Retina
Up-regulation in OIR
mmu-miR-351-5p	hsa-miR-125a-5p#	32	CDK1NA, CLEK5A	CD34	N/A	ARID3B, ERRB2
mmu-miR-762	hsa-miR-762	2	N/A	N/A	N/A	N/A
mmu-miR-210-3p	hsa-miR-210-3p	60	COL4A2	N/A	MNT	N/A
mmu-miR-145a-5p	hsa-miR-145-5p	164	CDH2, CDK6, CDKN1A, COL5A1, SERPINE1, NDRG2	ANGPT2, ETS1, SOX2	CTGF, ITGB8, MEST1, MMP1	CLINT1, MYO5A
mmu-miR-486a-5p	hsa-miR-486-5p	4	N/A	N/A	N/A	N/A
mmu-miR-339-5p	hsa-miR-339-5p	3	N/A	N/A	N/A	N/A
mmu-miR-34c-5p	hsa-miR-34c-5p	44	N/A	SOX2	N/A	N/A
mmu-miR-155-5p	hsa-miR-155-5p	294	N/A	DOCK1, ETS1, IL17RB	NOVA1	CKAP5, FADD, FAM177A1, MYO10
Down-regulation in OIR
mmu-miR-129-5p	hsa-miR-129-5p	15	CDK6	N/A	ABCC5	SOX4
mmu-miR-150-5p	hsa-miR-150-5p	34	N/A	NOTCH3, IGF2	IGF1	N/A
mmu-miR-375-3p	hsa-miR-375	39	N/A	RASD1	N/A	ERRB2
mmu-miR-203-3p	hsa-miR-203a-3p	63	CDK6	N/A	N/A	N/A
mmu-miR-129-2-3p	hsa-miR-129-2-3p	4	CDK6	N/A	N/A	SOX4
mmu-miR-449a-5p	hsa-miR-449a	30	CDK6, LEF1	N/A	N/A	N/A
mmu-miR-383-5p	hsa-miR-383-5p	8	IRF1	N/A	N/A	N/A
mmu-miR-1907	N/A	N/A	N/A	N/A	N/A	N/A
mmu-miR-409-3p	hsa-miR-409-3p	8	N/A	N/A	FGG	N/A

AMD, age-related macular degeneration; FVM, fibrovascular membrane; N/A, not applicable; NV, neovascular; PDR, proliferative diabetic retinopathy.

^*Experimentally validated miRNA human target interactions from qPCR, luciferase reporter assays, and Western blots were obtained from mirTarBase 6.1.

^#Hsa-miR-125a-5p contains identical seed sequence region as mmu-miR-351-5p, hence it was analyzed as the human homolog.