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. 2016 Sep 22;6:34056. doi: 10.1038/srep34056

Figure 1. NOR-1 and cIAP2 are over-expressed in human AAA tissues.

Figure 1

(a) NOR-1 and cIAP2 mRNA levels determined by real-time PCR in human AAA samples (black bars; n = 96) and human healthy aortic wall (Donors; white bars; n = 16). Data are expressed as mean ± s.e.m. *P < 0.01 vs. Donors; #P < 0.0001 vs. Donors. β-actin was used as endogenous control. (b) Representative western blot showing NOR-1 and cIAP2 protein levels in these tissues. Levels of β-actin were used as a loading control. (c) Positive statistical correlation between mRNA levels of NOR-1 and cIAP2 in patients and donors. The Spearman Rank Order Correlation after logarithmic transformation of data was applied (n = 112; r = 0.454; P < 0.000001). (d) Representative high magnification images showing the immunohistochemical analysis of NOR-1, and cIAP2 in consecutive sections from human healthy aortic wall samples (Donors; upper panels) and human AAA (middle panels). Large lower panels show low magnification images from AAA immunostaining. The position of the corresponding high power views squared. Bar = 50 μm (in high magnification images); Bar = 200 μm (in low magnification images). A: adventitia, m: media, and l: lumen.