Table 1. Number of cells found in different categories in various experiments. Significance values refer to the results of Fischer’s exact p value. Bold indicates significant difference.

Electrophysiology/Ca2+ imaging
Number of experiment	Description of experiment	Total number of capsaicin-responding neurons	Number of ACR neurons	Number of COR neurons	Significant difference
1	Whole-cell recordings from rat cultured PSN in control bath solution	39	29	10	From No 2: p = 0.82 From No 3: p = 0.65 From No 5: p = 0.1 From No 6: p = 0.36 From No 7: p = 0.009 From No 9: p = 0.28 From No 10: p = 0.4 From No 11: p = 1 From No 12: p = 0.08 From No 15: p = 1
2	Ca2+ imaging on rat PSN cultures	57	40	17	From No 1: p = 0.82 From No 3: p = 1 From No 9: p = 0.07 From No 10: p = 0.11
3	Ca2+ imaging in WT-TRPV1 mouse PSN cultures	54	37	17	From No 1 p = 0.65 From No 2: p = 1
4	Ca2+ imaging in TRPV1−/− mouse PSN cultures	0	n/a	n/a	n/a
5	Whole-cell recordings from IB4+ and IB4- cells	25	13	12	From No 1: p = 0.1 From No 6: 0.76 From No 12: p = 0.8
6	Whole-cell recordings from rat cultured PSN in the presence of rimonabant	18	11	7	From No 1: p = 0.36 From No 5: p = 0.76 From No 12: p = 0.79
7	Ca2+ imaging in WT-CB1 mouse PSN cultures	124	113	11	From No 1: p = 0.009 From No 2: p = 0.0005 From No 3: p = 0.016
8	Ca2+ imaging in CB1−/− mouse PSN cultures	115	74	41	From No 7: p < 0.0001
9	Ca2+ imaging in rat PSN cultures with a priori capsaicin application	197	161	36	From No 1: p = 0.28 From No 2: p = 0.07 From No 10: p = 0.71
10	Ca2+ imaging in rat PSN cultures with a priori capsaicin application and rimonabant application	237	190	47	From No 1: p = 0.4 From No 2: p = 0.11 From No 9: p = 0.71
11	Ca2+ imaging in rat PSN cultures with a priori capsaicin application and 1 μM NESS0237 application	34	25	9	From No 1: p = 1 From No 2: p = 0.81 From No 9: p = 0.35
12	Whole-cell recordings from rat cultured PSN for single cell PCR	56	31	25	From No 1: p = 0.08 From No 5: p = 0.8 From No 12: p = 0.79
Single-cell polymerase chain reaction
Number of experiment	Description of experiment	CB1 receptor expression in ACR neurons	CB1 receptor expression in COR neurons	CB1 receptor expression in NR neurons	Significant difference
13	Single-cell PCR using RNA from rat cultured PSN	11/11	8/10	4/8	n/a
Immunofluorescent staining
Number of experiment	Description of experiment	Total number of TRPV1-expressing cells	Number of TRPV1 and CB1 receptor expressing cells	Significant difference
14	Immunofluorescent staining	150	149	From number of capsaicin-responsive/CB1 mRNA expressing cells in No 12: p = 0.87
Electron microcopy
Number of experiment	Description of experiment	Total number of membrane patches analysed	Number of patches with high/medium receptor density	Number of patches with low receptor density	Significant difference from ACR/COR ratio
15	Immuno- electron microcopy	18	14	4	From No 1: p = 1 From No 2: p = 0.76 From No 9: p = 0.75 From No 12: p = 0.1