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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Ann N Y Acad Sci. 2016 May;1371(1):3–14. doi: 10.1111/nyas.13131

Figure 2.

Figure 2

Regulation of TFEB. Schematic representation of transcriptional and posttranslational regulation of TFEB. TFEB transcription is reinforced by at least two positive loops, one based on TFEB self-induction, and the other based on TFEB-mediated induction of the transcriptional co-activator PGC1α, which in turn promotes TFEB transcription. TFEB transcription is also positively regulated by CREB in competition with the negative regulator FRX. TFEB phosphorylation by mTORC1 triggers TFEB cytosolic retention by 14-3-3 proteins. Dephosphorylation of TFEB by calcineurin promotes TFEB nuclear translocation and activation of the CLEAR network.