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. Author manuscript; available in PMC: 2017 Jul 28.
Published in final edited form as: J Med Chem. 2016 Jul 13;59(14):6860–6877. doi: 10.1021/acs.jmedchem.6b00689

Figure 1.

Figure 1

Concentration-response study for all inhibitors compared to 1a and 2 at 50 μM, 20 μM, 1 μM, 500 nM, 100 nM, 20 nM and 10 nM. Percent residual activity of 38a was commensurate with 2 at most concentrations. Slope activity was determined between 0–40 min of assay activity time and determined as a percentage relative to DMSO.

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